Relation of stavudine discontinuation to anthropometric changes among HIV-infected women

Phyllis C. Tien, Michael Schneider, Stephen R. Cole, Jessica E. Justman, Audrey L. French, Mary Young, Jack DeHovitz, Niyati Nathwani, Todd T Brown

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation. DESIGN: Seven hundred thirty-four HIV-infected participants who reported using stavudine (574 of whom later discontinued stavudine) and 698 HIV-uninfected participants from the Women's Interagency HIV Study provided anthropometrics at 8706 semiannual visits between July 1999 and March 2005. METHODS: Changes in weight, waist, chest, upper arm, hip, and midthigh circumferences were evaluated using linear regression with generalized estimating equations. RESULTS: HIV-uninfected women demonstrated increases in regional anthropometry at every body site, whereas HIV-infected women demonstrated decreases in weight and circumferences of the waist, chest, hip, and thigh. A smaller annual decrease in hip circumference was seen after discontinuing stavudine for >2.25 years compared with the decrease observed while on stavudine (P = 0.01). Discontinuing stavudine for >2.25 years was associated with smaller (P <0.05) decreases in hip (-0.06 cm/y) and thigh (-0.005 cm/y) circumference compared with the decreases observed between 1 and 2.25 years (hip: -0.46 cm/y, thigh: -0.24 cm/y) or ≤1 year (hip: -0.64 cm/y, thigh: -0.27 cm/y) after stavudine discontinuation. CONCLUSIONS: Regardless of continuing or discontinuing stavudine, HIV-infected women demonstrate decreases in weight and body circumference measurements over time. The lower limb seems to be most affected by stavudine exposure, with stabilization observed more than 2 years after discontinuation.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume44
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Stavudine
HIV
Hip
Thigh
Anthropometry
Thorax
Weights and Measures
Waist Circumference
Lower Extremity
Linear Models
Arm
Body Weight

Keywords

  • Anthropometry
  • Antiretroviral therapy
  • HIV
  • Lipoatrophy
  • Stavudine

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Relation of stavudine discontinuation to anthropometric changes among HIV-infected women. / Tien, Phyllis C.; Schneider, Michael; Cole, Stephen R.; Justman, Jessica E.; French, Audrey L.; Young, Mary; DeHovitz, Jack; Nathwani, Niyati; Brown, Todd T.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 44, No. 1, 01.2007, p. 43-48.

Research output: Contribution to journalArticle

Tien, Phyllis C. ; Schneider, Michael ; Cole, Stephen R. ; Justman, Jessica E. ; French, Audrey L. ; Young, Mary ; DeHovitz, Jack ; Nathwani, Niyati ; Brown, Todd T. / Relation of stavudine discontinuation to anthropometric changes among HIV-infected women. In: Journal of Acquired Immune Deficiency Syndromes. 2007 ; Vol. 44, No. 1. pp. 43-48.
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abstract = "OBJECTIVE: To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation. DESIGN: Seven hundred thirty-four HIV-infected participants who reported using stavudine (574 of whom later discontinued stavudine) and 698 HIV-uninfected participants from the Women's Interagency HIV Study provided anthropometrics at 8706 semiannual visits between July 1999 and March 2005. METHODS: Changes in weight, waist, chest, upper arm, hip, and midthigh circumferences were evaluated using linear regression with generalized estimating equations. RESULTS: HIV-uninfected women demonstrated increases in regional anthropometry at every body site, whereas HIV-infected women demonstrated decreases in weight and circumferences of the waist, chest, hip, and thigh. A smaller annual decrease in hip circumference was seen after discontinuing stavudine for >2.25 years compared with the decrease observed while on stavudine (P = 0.01). Discontinuing stavudine for >2.25 years was associated with smaller (P <0.05) decreases in hip (-0.06 cm/y) and thigh (-0.005 cm/y) circumference compared with the decreases observed between 1 and 2.25 years (hip: -0.46 cm/y, thigh: -0.24 cm/y) or ≤1 year (hip: -0.64 cm/y, thigh: -0.27 cm/y) after stavudine discontinuation. CONCLUSIONS: Regardless of continuing or discontinuing stavudine, HIV-infected women demonstrate decreases in weight and body circumference measurements over time. The lower limb seems to be most affected by stavudine exposure, with stabilization observed more than 2 years after discontinuation.",
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AU - French, Audrey L.

AU - Young, Mary

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AB - OBJECTIVE: To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation. DESIGN: Seven hundred thirty-four HIV-infected participants who reported using stavudine (574 of whom later discontinued stavudine) and 698 HIV-uninfected participants from the Women's Interagency HIV Study provided anthropometrics at 8706 semiannual visits between July 1999 and March 2005. METHODS: Changes in weight, waist, chest, upper arm, hip, and midthigh circumferences were evaluated using linear regression with generalized estimating equations. RESULTS: HIV-uninfected women demonstrated increases in regional anthropometry at every body site, whereas HIV-infected women demonstrated decreases in weight and circumferences of the waist, chest, hip, and thigh. A smaller annual decrease in hip circumference was seen after discontinuing stavudine for >2.25 years compared with the decrease observed while on stavudine (P = 0.01). Discontinuing stavudine for >2.25 years was associated with smaller (P <0.05) decreases in hip (-0.06 cm/y) and thigh (-0.005 cm/y) circumference compared with the decreases observed between 1 and 2.25 years (hip: -0.46 cm/y, thigh: -0.24 cm/y) or ≤1 year (hip: -0.64 cm/y, thigh: -0.27 cm/y) after stavudine discontinuation. CONCLUSIONS: Regardless of continuing or discontinuing stavudine, HIV-infected women demonstrate decreases in weight and body circumference measurements over time. The lower limb seems to be most affected by stavudine exposure, with stabilization observed more than 2 years after discontinuation.

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