Relation of stavudine discontinuation to anthropometric changes among HIV-infected women

Phyllis C. Tien, Michael F. Schneider, Stephen R. Cole, Jessica E. Justman, Audrey L. French, Mary Young, Jack DeHovitz, Niyati Nathwani, Todd T. Brown

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation. DESIGN: Seven hundred thirty-four HIV-infected participants who reported using stavudine (574 of whom later discontinued stavudine) and 698 HIV-uninfected participants from the Women's Interagency HIV Study provided anthropometrics at 8706 semiannual visits between July 1999 and March 2005. METHODS: Changes in weight, waist, chest, upper arm, hip, and midthigh circumferences were evaluated using linear regression with generalized estimating equations. RESULTS: HIV-uninfected women demonstrated increases in regional anthropometry at every body site, whereas HIV-infected women demonstrated decreases in weight and circumferences of the waist, chest, hip, and thigh. A smaller annual decrease in hip circumference was seen after discontinuing stavudine for >2.25 years compared with the decrease observed while on stavudine (P = 0.01). Discontinuing stavudine for >2.25 years was associated with smaller (P < 0.05) decreases in hip (-0.06 cm/y) and thigh (-0.005 cm/y) circumference compared with the decreases observed between 1 and 2.25 years (hip: -0.46 cm/y, thigh: -0.24 cm/y) or ≤1 year (hip: -0.64 cm/y, thigh: -0.27 cm/y) after stavudine discontinuation. CONCLUSIONS: Regardless of continuing or discontinuing stavudine, HIV-infected women demonstrate decreases in weight and body circumference measurements over time. The lower limb seems to be most affected by stavudine exposure, with stabilization observed more than 2 years after discontinuation.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume44
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Anthropometry
  • Antiretroviral therapy
  • HIV
  • Lipoatrophy
  • Stavudine

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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