Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction

Doron Aronson, Diab Mutlak, Jonathan Lessick, Michael Kapeliovich, Salim Dabbah, Walter Markiewicz, Rafael Beyar, Haim Hammerman, Shimon Reisner, Yoram Agmon

Research output: Contribution to journalArticle

Abstract

Recent studies suggest that statin therapy reduces hospitalizations for heart failure (HF). However, few data exist regarding the role of statins in preventing HF after acute myocardial infarction (AMI). In addition, the potential impact of left ventricular (LV) ejection fraction (EF) and coexisting functional mitral regurgitation (MR) on the efficacy of statin therapy was not considered. We prospectively studied 1,563 patients with AMI. The primary endpoint was readmission for the treatment of HF. The effect of statin therapy initiated before hospital discharge was evaluated using a Cox model, adjusting for clinical variables, a propensity score for statin therapy, LVEF, and MR grade. Patients with recurrent infarctions were censored. Statins were prescribed in 1,048 patients (67.1%) before hospital discharge. During a median follow-up of 17 months, admissions for HF were lower in patients receiving statins (6.5% vs 14.8%; unadjusted hazard ratio 0.45, 95% confidence interval 0.32 to 0.63, p

Original languageEnglish (US)
Pages (from-to)1706-1710
Number of pages5
JournalThe American Journal of Cardiology
Volume102
Issue number12
DOIs
StatePublished - Dec 15 2008
Externally publishedYes

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Heart Failure
Myocardial Infarction
Mitral Valve Insufficiency
Therapeutics
Propensity Score
Treatment Failure
Proportional Hazards Models
Stroke Volume
Infarction
Hospitalization
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Aronson, D., Mutlak, D., Lessick, J., Kapeliovich, M., Dabbah, S., Markiewicz, W., ... Agmon, Y. (2008). Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction. The American Journal of Cardiology, 102(12), 1706-1710. https://doi.org/10.1016/j.amjcard.2008.07.057

Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction. / Aronson, Doron; Mutlak, Diab; Lessick, Jonathan; Kapeliovich, Michael; Dabbah, Salim; Markiewicz, Walter; Beyar, Rafael; Hammerman, Haim; Reisner, Shimon; Agmon, Yoram.

In: The American Journal of Cardiology, Vol. 102, No. 12, 15.12.2008, p. 1706-1710.

Research output: Contribution to journalArticle

Aronson, D, Mutlak, D, Lessick, J, Kapeliovich, M, Dabbah, S, Markiewicz, W, Beyar, R, Hammerman, H, Reisner, S & Agmon, Y 2008, 'Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction', The American Journal of Cardiology, vol. 102, no. 12, pp. 1706-1710. https://doi.org/10.1016/j.amjcard.2008.07.057
Aronson D, Mutlak D, Lessick J, Kapeliovich M, Dabbah S, Markiewicz W et al. Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction. The American Journal of Cardiology. 2008 Dec 15;102(12):1706-1710. https://doi.org/10.1016/j.amjcard.2008.07.057
Aronson, Doron ; Mutlak, Diab ; Lessick, Jonathan ; Kapeliovich, Michael ; Dabbah, Salim ; Markiewicz, Walter ; Beyar, Rafael ; Hammerman, Haim ; Reisner, Shimon ; Agmon, Yoram. / Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction. In: The American Journal of Cardiology. 2008 ; Vol. 102, No. 12. pp. 1706-1710.
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