TY - JOUR
T1 - Relation of Statin Therapy to Risk of Heart Failure After Acute Myocardial Infarction
AU - Aronson, Doron
AU - Mutlak, Diab
AU - Lessick, Jonathan
AU - Kapeliovich, Michael
AU - Dabbah, Salim
AU - Markiewicz, Walter
AU - Beyar, Rafael
AU - Hammerman, Haim
AU - Reisner, Shimon
AU - Agmon, Yoram
PY - 2008/12/15
Y1 - 2008/12/15
N2 - Recent studies suggest that statin therapy reduces hospitalizations for heart failure (HF). However, few data exist regarding the role of statins in preventing HF after acute myocardial infarction (AMI). In addition, the potential impact of left ventricular (LV) ejection fraction (EF) and coexisting functional mitral regurgitation (MR) on the efficacy of statin therapy was not considered. We prospectively studied 1,563 patients with AMI. The primary endpoint was readmission for the treatment of HF. The effect of statin therapy initiated before hospital discharge was evaluated using a Cox model, adjusting for clinical variables, a propensity score for statin therapy, LVEF, and MR grade. Patients with recurrent infarctions were censored. Statins were prescribed in 1,048 patients (67.1%) before hospital discharge. During a median follow-up of 17 months, admissions for HF were lower in patients receiving statins (6.5% vs 14.8%; unadjusted hazard ratio 0.45, 95% confidence interval 0.32 to 0.63, p
AB - Recent studies suggest that statin therapy reduces hospitalizations for heart failure (HF). However, few data exist regarding the role of statins in preventing HF after acute myocardial infarction (AMI). In addition, the potential impact of left ventricular (LV) ejection fraction (EF) and coexisting functional mitral regurgitation (MR) on the efficacy of statin therapy was not considered. We prospectively studied 1,563 patients with AMI. The primary endpoint was readmission for the treatment of HF. The effect of statin therapy initiated before hospital discharge was evaluated using a Cox model, adjusting for clinical variables, a propensity score for statin therapy, LVEF, and MR grade. Patients with recurrent infarctions were censored. Statins were prescribed in 1,048 patients (67.1%) before hospital discharge. During a median follow-up of 17 months, admissions for HF were lower in patients receiving statins (6.5% vs 14.8%; unadjusted hazard ratio 0.45, 95% confidence interval 0.32 to 0.63, p
UR - http://www.scopus.com/inward/record.url?scp=58949105089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58949105089&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2008.07.057
DO - 10.1016/j.amjcard.2008.07.057
M3 - Article
C2 - 19064028
AN - SCOPUS:58949105089
SN - 0002-9149
VL - 102
SP - 1706
EP - 1710
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 12
ER -