TY - JOUR
T1 - Relation of Sex Hormone Levels with Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI
T2 - The Multi-Ethnic Study of Atherosclerosis
AU - Subramanya, Vinita
AU - Ambale-Venkatesh, Bharath
AU - Ohyama, Yoshiaki
AU - Zhao, Di
AU - Nwabuo, Chike C.
AU - Post, Wendy S.
AU - Guallar, Eliseo
AU - Ouyang, Pamela
AU - Shah, Sanjiv J.
AU - Allison, Matthew A.
AU - Ndumele, Chiadi E.
AU - Vaidya, Dhananjay
AU - Bluemke, David A.
AU - Lima, Joao A.
AU - Michos, Erin D.
N1 - Funding Information:
The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. Dr Subramanya’s fellowship and this work was supported by the American Heart Association (AHA) Go Red for Women Strategic Focused Research Network contract AHA 16SFRN27870000. Drs. Michos and Zhao were supported by the Blumenthal Scholars Fund for Preventive Cardiology Research. Dr Shah is supported by National Institutes of Health (NIH) National Heart, Lung, and Blood Institute grants R01 HL107577 and R01 HL127028, and by AHA grant #16SFRN28780016. The MESA study was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the NIH National Heart, Lung, and Blood Institute, and by R01 HL074406 and R01 HL074338.
Funding Information:
The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. Dr Subramanya's fellowship and this work was supported by the American Heart Association (AHA) Go Red for Women Strategic Focused Research Network contract AHA 16SFRN27870000. Drs. Michos and Zhao were supported by the Blumenthal Scholars Fund for Preventive Cardiology Research. Dr Shah is supported by National Institutes of Health (NIH) National Heart, Lung, and Blood Institute grants R01 HL107577 and R01 HL127028, and by AHA grant #16SFRN28780016. The MESA study was supported by contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the NIH National Heart, Lung, and Blood Institute, and by R01 HL074406 and R01 HL074338.
Funding Information:
Unrelated to this work, Dr Michos has received an honorarium from Siemens Healthcare Diagnostics for being a blinded medical events adjudicator for a clinical trial (in 2016). Dr Ouyang has research grant support from Cordex Systems. Other authors declared no conflict of interest.
Publisher Copyright:
© 2018 American Journal of Hypertension, Ltd. All rights reserved.
PY - 2018/6/11
Y1 - 2018/6/11
N2 - Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.
AB - Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.
KW - aortic distensibility
KW - blood pressure
KW - epidemiology
KW - hypertension
KW - magnetic resonance imaging
KW - sex differences
KW - sex hormones
KW - vascular stiffness
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U2 - 10.1093/ajh/hpy024
DO - 10.1093/ajh/hpy024
M3 - Article
C2 - 29471444
AN - SCOPUS:85048693653
VL - 31
SP - 774
EP - 783
JO - American journal of hypertension
JF - American journal of hypertension
SN - 0895-7061
IS - 7
ER -