Relation of Sex Hormone Levels with Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis

Vinita Subramanya, Bharath Ambale Venkatesh, Yoshiaki Ohyama, Di Zhao, Chike C. Nwabuo, Wendy S Post, Eliseo Guallar, Pamela Ouyang, Sanjiv J. Shah, Matthew A. Allison, Chiadi Ericson Ndumele, Dhananjay Vaidya, David A. Bluemke, Joao Lima, Erin Donnelly Michos

Research output: Contribution to journalArticle

Abstract

Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.

Original languageEnglish (US)
Pages (from-to)774-783
Number of pages10
JournalAmerican Journal of Hypertension
Volume31
Issue number7
DOIs
StatePublished - Jun 11 2018

Fingerprint

Gonadal Steroid Hormones
Atherosclerosis
Testosterone
Estradiol
Magnetic Resonance Imaging
Elasticity
Body Size
Menopause
Sample Size
Life Style
Linear Models
Arterial Pressure
Cross-Sectional Studies
Heart Rate
Demography
Hormones
Serum

Keywords

  • aortic distensibility
  • blood pressure
  • epidemiology
  • hypertension
  • magnetic resonance imaging
  • sex differences
  • sex hormones
  • vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine

Cite this

@article{fb7540996b0545a9bb59c33a02be53db,
title = "Relation of Sex Hormone Levels with Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis",
abstract = "Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50{\%} at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.",
keywords = "aortic distensibility, blood pressure, epidemiology, hypertension, magnetic resonance imaging, sex differences, sex hormones, vascular stiffness",
author = "Vinita Subramanya and {Ambale Venkatesh}, Bharath and Yoshiaki Ohyama and Di Zhao and Nwabuo, {Chike C.} and Post, {Wendy S} and Eliseo Guallar and Pamela Ouyang and Shah, {Sanjiv J.} and Allison, {Matthew A.} and Ndumele, {Chiadi Ericson} and Dhananjay Vaidya and Bluemke, {David A.} and Joao Lima and Michos, {Erin Donnelly}",
year = "2018",
month = "6",
day = "11",
doi = "10.1093/ajh/hpy024",
language = "English (US)",
volume = "31",
pages = "774--783",
journal = "Journal of clinical hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Relation of Sex Hormone Levels with Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI

T2 - The Multi-Ethnic Study of Atherosclerosis

AU - Subramanya, Vinita

AU - Ambale Venkatesh, Bharath

AU - Ohyama, Yoshiaki

AU - Zhao, Di

AU - Nwabuo, Chike C.

AU - Post, Wendy S

AU - Guallar, Eliseo

AU - Ouyang, Pamela

AU - Shah, Sanjiv J.

AU - Allison, Matthew A.

AU - Ndumele, Chiadi Ericson

AU - Vaidya, Dhananjay

AU - Bluemke, David A.

AU - Lima, Joao

AU - Michos, Erin Donnelly

PY - 2018/6/11

Y1 - 2018/6/11

N2 - Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.

AB - Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 postmenopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline. Among these participants, 457 women and 548 men returned for follow-up magnetic resonance imaging 10-years later. Stratified by sex, and using mixed effects linear regression methods, we examined associations of sex hormones (as tertiles) with baseline and annual change in log-transformed AAD (mm Hg-110-3), adjusting for demographics, body size, lifestyle factors, mean arterial pressure, heart rate, hypertensive medication use (and in women, for hormone therapy use and years since menopause). Results: The mean (SD) age was 65 (9) for women and 62 (10) years for men. AAD was lower in women than men (P < 0.001). In adjusted cross-sectional analysis, the highest tertile of free testosterone (compared to lowest) in women was significantly associated with lower AAD [-0.10 (-0.19, -0.01)] and the highest tertile of estradiol in men was associated with greater AAD [0.12 (0.04, 0.20)]. There were no associations of sex hormones with change in AAD over 10 years, albeit in a smaller sample size. Conclusions: Lower free testosterone in women and higher estradiol in men were associated with greater aortic distensibility at baseline, but not longitudinally. Sex hormone levels may account for differences in AAD between women and men.

KW - aortic distensibility

KW - blood pressure

KW - epidemiology

KW - hypertension

KW - magnetic resonance imaging

KW - sex differences

KW - sex hormones

KW - vascular stiffness

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U2 - 10.1093/ajh/hpy024

DO - 10.1093/ajh/hpy024

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AN - SCOPUS:85048693653

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JF - Journal of clinical hypertension

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