Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA

Amanda Kyle Scofield, Lida Radfar, John A. Ice, Evan Vista, Juan Manuel Anaya, Glen Houston, David Lewis, Donald U. Stone, James Chodosh, Kimberly Hefner, Christopher J. Lessard, Kathy L. Moser, Robert Hal Scofield

Research output: Contribution to journalArticle

Abstract

Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

Original languageEnglish (US)
Pages (from-to)290-293
Number of pages4
JournalJournal of Clinical Rheumatology
Volume18
Issue number6
DOIs
StatePublished - Sep 2012
Externally publishedYes

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Peripheral Nervous System Diseases
Immunodiffusion
Vitamin B 12
Proprioception
Lacrimal Apparatus
Neurologic Examination
Touch
Salivary Glands
Serum
Nervous System
Autoimmune Diseases
Mouth
Chronic Disease
Odds Ratio
Inflammation
Enzymes

Keywords

  • Autoantibodies
  • Peripheral neuropathy
  • Sjögren syndrome
  • Vitamin B

ASJC Scopus subject areas

  • Rheumatology

Cite this

Scofield, A. K., Radfar, L., Ice, J. A., Vista, E., Anaya, J. M., Houston, G., ... Scofield, R. H. (2012). Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA. Journal of Clinical Rheumatology, 18(6), 290-293. https://doi.org/10.1097/RHU.0b013e3182675e4f

Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA. / Scofield, Amanda Kyle; Radfar, Lida; Ice, John A.; Vista, Evan; Anaya, Juan Manuel; Houston, Glen; Lewis, David; Stone, Donald U.; Chodosh, James; Hefner, Kimberly; Lessard, Christopher J.; Moser, Kathy L.; Scofield, Robert Hal.

In: Journal of Clinical Rheumatology, Vol. 18, No. 6, 09.2012, p. 290-293.

Research output: Contribution to journalArticle

Scofield, AK, Radfar, L, Ice, JA, Vista, E, Anaya, JM, Houston, G, Lewis, D, Stone, DU, Chodosh, J, Hefner, K, Lessard, CJ, Moser, KL & Scofield, RH 2012, 'Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA', Journal of Clinical Rheumatology, vol. 18, no. 6, pp. 290-293. https://doi.org/10.1097/RHU.0b013e3182675e4f
Scofield, Amanda Kyle ; Radfar, Lida ; Ice, John A. ; Vista, Evan ; Anaya, Juan Manuel ; Houston, Glen ; Lewis, David ; Stone, Donald U. ; Chodosh, James ; Hefner, Kimberly ; Lessard, Christopher J. ; Moser, Kathy L. ; Scofield, Robert Hal. / Relation of sensory peripheral neuropathy in sjögren syndrome to Anti-Ro/SSA. In: Journal of Clinical Rheumatology. 2012 ; Vol. 18, No. 6. pp. 290-293.
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abstract = "Background: Sj{\"o}gren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sj{\"o}gren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31{\%}) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1{\%}) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sj{\"o}gren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sj{\"o}gren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.",
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AU - Radfar, Lida

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AU - Vista, Evan

AU - Anaya, Juan Manuel

AU - Houston, Glen

AU - Lewis, David

AU - Stone, Donald U.

AU - Chodosh, James

AU - Hefner, Kimberly

AU - Lessard, Christopher J.

AU - Moser, Kathy L.

AU - Scofield, Robert Hal

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N2 - Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

AB - Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods: Eight-eight patients attending a dry eyesYdry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (W2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti- La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (W2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

KW - Autoantibodies

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KW - Sjögren syndrome

KW - Vitamin B

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