Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair

Mark K. Friedberg, Fernanda P. Fernandes, Susan L. Roche, Cameron Slorach, Lars Grosse-Wortmann, Cedric Manlhiot, Cheryl Fackoury, Brian W. McCrindle, Luc Mertens, Paul F. Kantor

Research output: Contribution to journalArticle

Abstract

Background Progressive right ventricular (RV) dysfunction and exercise intolerance are common problems after tetralogy of Fallot (TOF) repair. We investigated RV myocardial deformation and dyssynchrony in children after TOF repair and their association with exercise capacity. Methods Asymptomatic children after TOF repair were investigated by 2-dimensional speckle tracking echocardiography, magnetic resonance, and metabolic exercise study. Patients with RV outflow obstruction were excluded. Peak RV longitudinal strain and strain rate (SR) and dyssynchrony (RV intraventricular delay) were compared with healthy controls. Associations between RV strain, dyssynchrony, and exercise capacity were analyzed. Results Thirty-nine (81%) of 48 TOF patients and 40 healthy controls had adequate RV strain imaging. The TOF patients had moderately dilated RVs and normal RV ejection fraction. Right ventricular peak systolic strain (-23.2% ± 5.1% vs -28.5% ± 8.5%, P <.001) and SR (-1.46 ± 0.68 vs -2.1 ± 0.8, P <.001) were reduced in TOF patients compared with controls. Right ventricular intraventricular delay was higher in TOF patients (146.0 ± 159 vs 71.0 ± 92 milliseconds, P =.008). Decreased RV strain and SR were associated with increased RV dyssynchrony (strain parameter estimate [PE] 6.31 [2.30], P =.007; SR [PE] 11.32 [3.84], P =.004). Increased RV-left ventricular delay was associated with prolonged QRS duration (PE 0.13 [0.058], P =.03) and reduced RV ejection fraction (PE -2.95 [1.275], P =.02). Reduced RV peak SR was associated with decreased exercise peak oxygen uptake (PE 0.14 [0.07], P =.04). Conclusions After repair of TOF, asymptomatic children have reduced RV deformation in association with RV dyssynchrony and reduced exercise tolerance.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalAmerican heart journal
Volume165
Issue number4
DOIs
StatePublished - Apr 1 2013
Externally publishedYes

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Exercise Tolerance
Tetralogy of Fallot
Mechanics
Exercise
Stroke Volume
Right Ventricular Dysfunction
Ventricular Outflow Obstruction
Patient Rights
Echocardiography
Magnetic Resonance Spectroscopy
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Friedberg, M. K., Fernandes, F. P., Roche, S. L., Slorach, C., Grosse-Wortmann, L., Manlhiot, C., ... Kantor, P. F. (2013). Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair. American heart journal, 165(4), 551-557. https://doi.org/10.1016/j.ahj.2012.06.029

Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair. / Friedberg, Mark K.; Fernandes, Fernanda P.; Roche, Susan L.; Slorach, Cameron; Grosse-Wortmann, Lars; Manlhiot, Cedric; Fackoury, Cheryl; McCrindle, Brian W.; Mertens, Luc; Kantor, Paul F.

In: American heart journal, Vol. 165, No. 4, 01.04.2013, p. 551-557.

Research output: Contribution to journalArticle

Friedberg, MK, Fernandes, FP, Roche, SL, Slorach, C, Grosse-Wortmann, L, Manlhiot, C, Fackoury, C, McCrindle, BW, Mertens, L & Kantor, PF 2013, 'Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair', American heart journal, vol. 165, no. 4, pp. 551-557. https://doi.org/10.1016/j.ahj.2012.06.029
Friedberg, Mark K. ; Fernandes, Fernanda P. ; Roche, Susan L. ; Slorach, Cameron ; Grosse-Wortmann, Lars ; Manlhiot, Cedric ; Fackoury, Cheryl ; McCrindle, Brian W. ; Mertens, Luc ; Kantor, Paul F. / Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair. In: American heart journal. 2013 ; Vol. 165, No. 4. pp. 551-557.
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abstract = "Background Progressive right ventricular (RV) dysfunction and exercise intolerance are common problems after tetralogy of Fallot (TOF) repair. We investigated RV myocardial deformation and dyssynchrony in children after TOF repair and their association with exercise capacity. Methods Asymptomatic children after TOF repair were investigated by 2-dimensional speckle tracking echocardiography, magnetic resonance, and metabolic exercise study. Patients with RV outflow obstruction were excluded. Peak RV longitudinal strain and strain rate (SR) and dyssynchrony (RV intraventricular delay) were compared with healthy controls. Associations between RV strain, dyssynchrony, and exercise capacity were analyzed. Results Thirty-nine (81{\%}) of 48 TOF patients and 40 healthy controls had adequate RV strain imaging. The TOF patients had moderately dilated RVs and normal RV ejection fraction. Right ventricular peak systolic strain (-23.2{\%} ± 5.1{\%} vs -28.5{\%} ± 8.5{\%}, P <.001) and SR (-1.46 ± 0.68 vs -2.1 ± 0.8, P <.001) were reduced in TOF patients compared with controls. Right ventricular intraventricular delay was higher in TOF patients (146.0 ± 159 vs 71.0 ± 92 milliseconds, P =.008). Decreased RV strain and SR were associated with increased RV dyssynchrony (strain parameter estimate [PE] 6.31 [2.30], P =.007; SR [PE] 11.32 [3.84], P =.004). Increased RV-left ventricular delay was associated with prolonged QRS duration (PE 0.13 [0.058], P =.03) and reduced RV ejection fraction (PE -2.95 [1.275], P =.02). Reduced RV peak SR was associated with decreased exercise peak oxygen uptake (PE 0.14 [0.07], P =.04). Conclusions After repair of TOF, asymptomatic children have reduced RV deformation in association with RV dyssynchrony and reduced exercise tolerance.",
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T1 - Relation of right ventricular mechanics to exercise tolerance in children after tetralogy of Fallot repair

AU - Friedberg, Mark K.

AU - Fernandes, Fernanda P.

AU - Roche, Susan L.

AU - Slorach, Cameron

AU - Grosse-Wortmann, Lars

AU - Manlhiot, Cedric

AU - Fackoury, Cheryl

AU - McCrindle, Brian W.

AU - Mertens, Luc

AU - Kantor, Paul F.

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N2 - Background Progressive right ventricular (RV) dysfunction and exercise intolerance are common problems after tetralogy of Fallot (TOF) repair. We investigated RV myocardial deformation and dyssynchrony in children after TOF repair and their association with exercise capacity. Methods Asymptomatic children after TOF repair were investigated by 2-dimensional speckle tracking echocardiography, magnetic resonance, and metabolic exercise study. Patients with RV outflow obstruction were excluded. Peak RV longitudinal strain and strain rate (SR) and dyssynchrony (RV intraventricular delay) were compared with healthy controls. Associations between RV strain, dyssynchrony, and exercise capacity were analyzed. Results Thirty-nine (81%) of 48 TOF patients and 40 healthy controls had adequate RV strain imaging. The TOF patients had moderately dilated RVs and normal RV ejection fraction. Right ventricular peak systolic strain (-23.2% ± 5.1% vs -28.5% ± 8.5%, P <.001) and SR (-1.46 ± 0.68 vs -2.1 ± 0.8, P <.001) were reduced in TOF patients compared with controls. Right ventricular intraventricular delay was higher in TOF patients (146.0 ± 159 vs 71.0 ± 92 milliseconds, P =.008). Decreased RV strain and SR were associated with increased RV dyssynchrony (strain parameter estimate [PE] 6.31 [2.30], P =.007; SR [PE] 11.32 [3.84], P =.004). Increased RV-left ventricular delay was associated with prolonged QRS duration (PE 0.13 [0.058], P =.03) and reduced RV ejection fraction (PE -2.95 [1.275], P =.02). Reduced RV peak SR was associated with decreased exercise peak oxygen uptake (PE 0.14 [0.07], P =.04). Conclusions After repair of TOF, asymptomatic children have reduced RV deformation in association with RV dyssynchrony and reduced exercise tolerance.

AB - Background Progressive right ventricular (RV) dysfunction and exercise intolerance are common problems after tetralogy of Fallot (TOF) repair. We investigated RV myocardial deformation and dyssynchrony in children after TOF repair and their association with exercise capacity. Methods Asymptomatic children after TOF repair were investigated by 2-dimensional speckle tracking echocardiography, magnetic resonance, and metabolic exercise study. Patients with RV outflow obstruction were excluded. Peak RV longitudinal strain and strain rate (SR) and dyssynchrony (RV intraventricular delay) were compared with healthy controls. Associations between RV strain, dyssynchrony, and exercise capacity were analyzed. Results Thirty-nine (81%) of 48 TOF patients and 40 healthy controls had adequate RV strain imaging. The TOF patients had moderately dilated RVs and normal RV ejection fraction. Right ventricular peak systolic strain (-23.2% ± 5.1% vs -28.5% ± 8.5%, P <.001) and SR (-1.46 ± 0.68 vs -2.1 ± 0.8, P <.001) were reduced in TOF patients compared with controls. Right ventricular intraventricular delay was higher in TOF patients (146.0 ± 159 vs 71.0 ± 92 milliseconds, P =.008). Decreased RV strain and SR were associated with increased RV dyssynchrony (strain parameter estimate [PE] 6.31 [2.30], P =.007; SR [PE] 11.32 [3.84], P =.004). Increased RV-left ventricular delay was associated with prolonged QRS duration (PE 0.13 [0.058], P =.03) and reduced RV ejection fraction (PE -2.95 [1.275], P =.02). Reduced RV peak SR was associated with decreased exercise peak oxygen uptake (PE 0.14 [0.07], P =.04). Conclusions After repair of TOF, asymptomatic children have reduced RV deformation in association with RV dyssynchrony and reduced exercise tolerance.

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