TY - JOUR
T1 - Relation of Plasma Lipoprotein Levels With Low-Grade Inflammation in White Men Without Clinical Evidence of Myocardial Ischemia
AU - Rivera, Juan J.
AU - Nasir, Khurram
AU - Campbell, Catherine
AU - Carvalho, Jose A.M.
AU - Blumenthal, Roger S.
AU - Santos, Raul D.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - There is a growing body of evidence indicating that high triglyceride levels are an independent risk factor for cardiovascular disease (CVD) events. In this study we compared the association of fasting levels of non-high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, and triglycerides with white blood cell (WBC) count, an inflammatory marker associated with an adverse CVD prognosis. We studied 458 asymptomatic men (46.0 ± 7.0 years old) who presented for CVD risk stratification. WBC count (×109 cells/L) increased significantly across increasing tertiles of triglyceride level (tertile 1, 6.04 ± 1.49; tertile 2 6.21 ± 1.44; tertile 3 6.78 ± 1.73, p <0.0001), whereas a trend of lower WBC counts was observed across increasing tertiles of HDL cholesterol (tertile 1, 6.52 ± 1.62; tertile 2, 6.24 ± 1.50; tertile 3, 6.21 ± 1.61, p = 0.08). In models adjusted for age, gender, and CVD risk factor, the odds ratio for a high WBC count (quartile ≥4 vs lower 3 quartiles) was significantly higher with increasing levels of triglyceride (2.4, 95% confidence interval 1.3 to 4.8, p = 0.02). When all lipid variables were introduced in the models in addition to traditional CVD risk factors, the association between plasma triglyceride level and WBC count persisted (p = 0.04), which was not found for other lipid parameters. In conclusion, in our study, only plasma triglyceride level was independently associated with a higher WBC count.
AB - There is a growing body of evidence indicating that high triglyceride levels are an independent risk factor for cardiovascular disease (CVD) events. In this study we compared the association of fasting levels of non-high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, HDL cholesterol, and triglycerides with white blood cell (WBC) count, an inflammatory marker associated with an adverse CVD prognosis. We studied 458 asymptomatic men (46.0 ± 7.0 years old) who presented for CVD risk stratification. WBC count (×109 cells/L) increased significantly across increasing tertiles of triglyceride level (tertile 1, 6.04 ± 1.49; tertile 2 6.21 ± 1.44; tertile 3 6.78 ± 1.73, p <0.0001), whereas a trend of lower WBC counts was observed across increasing tertiles of HDL cholesterol (tertile 1, 6.52 ± 1.62; tertile 2, 6.24 ± 1.50; tertile 3, 6.21 ± 1.61, p = 0.08). In models adjusted for age, gender, and CVD risk factor, the odds ratio for a high WBC count (quartile ≥4 vs lower 3 quartiles) was significantly higher with increasing levels of triglyceride (2.4, 95% confidence interval 1.3 to 4.8, p = 0.02). When all lipid variables were introduced in the models in addition to traditional CVD risk factors, the association between plasma triglyceride level and WBC count persisted (p = 0.04), which was not found for other lipid parameters. In conclusion, in our study, only plasma triglyceride level was independently associated with a higher WBC count.
UR - http://www.scopus.com/inward/record.url?scp=34447621247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447621247&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2007.03.044
DO - 10.1016/j.amjcard.2007.03.044
M3 - Article
C2 - 17659927
AN - SCOPUS:34447621247
SN - 0002-9149
VL - 100
SP - 450
EP - 454
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -