Relation of leptin to left ventricular hypertrophy (from the multi-ethnic study of atherosclerosis)

Matthew A. Allison, David A. Bluemke, Robyn McClelland, Mary Cushman, Michael H. Criqui, Joseph F. Polak, Joao Lima

Research output: Contribution to journalArticle

Abstract

Increasing adiposity increases the risk for left ventricular (LV) hypertrophy. Adipokines are hormone-like substances from adipose tissue that influence several metabolic pathways relevant to LV hypertrophy. Data were obtained from participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent magnetic resonance imaging of the heart and who also had fasting venous blood assayed for 4 distinct adipokines (adiponectin, leptin, tumor necrosis factor-α, and resistin). One-thousand four hundred sixty four MESA participants had complete data. The mean age was 61.5 years, the mean body mass index was 27.6 kg/m2, and 49% were women. With adjustment for age, gender, race, height, and weight, multivariate linear regression modeling revealed that a 1-SD increment in leptin was significantly associated with smaller LV mass (ß: -4.66% predicted, p

Original languageEnglish (US)
Pages (from-to)726-730
Number of pages5
JournalThe American Journal of Cardiology
Volume112
Issue number5
DOIs
StatePublished - Sep 1 2013

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Adipokines
Left Ventricular Hypertrophy
Leptin
Atherosclerosis
Resistin
Adiponectin
Adiposity
Metabolic Networks and Pathways
Adipose Tissue
Linear Models
Fasting
Body Mass Index
Tumor Necrosis Factor-alpha
Magnetic Resonance Imaging
Hormones
Weights and Measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of leptin to left ventricular hypertrophy (from the multi-ethnic study of atherosclerosis). / Allison, Matthew A.; Bluemke, David A.; McClelland, Robyn; Cushman, Mary; Criqui, Michael H.; Polak, Joseph F.; Lima, Joao.

In: The American Journal of Cardiology, Vol. 112, No. 5, 01.09.2013, p. 726-730.

Research output: Contribution to journalArticle

Allison, Matthew A. ; Bluemke, David A. ; McClelland, Robyn ; Cushman, Mary ; Criqui, Michael H. ; Polak, Joseph F. ; Lima, Joao. / Relation of leptin to left ventricular hypertrophy (from the multi-ethnic study of atherosclerosis). In: The American Journal of Cardiology. 2013 ; Vol. 112, No. 5. pp. 726-730.
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