TY - JOUR
T1 - Relation of family history of premature coronary heart disease and metabolic risk factors to risk of coronary arterial calcium in asymptomatic subjects
AU - Michos, Erin D.
AU - Nasir, Khurram
AU - Rumberger, John A.
AU - Vasamreddy, Chandra
AU - Braunstein, Joel B.
AU - Budoff, Matthew J.
AU - Blumenthal, Roger S.
N1 - Funding Information:
This work was supported by an unrestricted educational grant by the Maryland Athletic Club Charitable Foundation, Lutherville, Maryland.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC <100, and CAC <75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of <2 metabolic RFs, magnifying the risks for those exposed to both.
AB - We studied 6,141 consecutive, asymptomatic, nondiabetic patients who underwent electron beam tomography and explored the interaction between metabolic risk factors (RFs) and premature family history (FH) of coronary heart disease (CHD) in predicting the presence and severity of coronary arterial calcium (CAC). In the presence of >2 metabolic RFs, patients with a positive FH of premature CHD had a significantly higher prevalence of any CAC, CAC <100, and CAC <75th age-gender percentile than those without a FH of CHD. Our study demonstrated that a familial propensity to subclinical atherosclerosis interacts with the presence of <2 metabolic RFs, magnifying the risks for those exposed to both.
UR - http://www.scopus.com/inward/record.url?scp=13844281139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844281139&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2004.10.045
DO - 10.1016/j.amjcard.2004.10.045
M3 - Article
C2 - 15721113
AN - SCOPUS:13844281139
SN - 0002-9149
VL - 95
SP - 655
EP - 657
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 5
ER -