TY - JOUR
T1 - Relation of exercise and pain in patients with idiopathic distal axonal polyneuropathies
AU - Stewart, Sarah
AU - Thomas, Simone
AU - Van Doormaal, Perry T.C.
AU - Höke, Ahmet
N1 - Funding Information:
We thank the patients, their families, and the Foundation of Peripheral Neuropathy for their support of the PNRR. We also thank the consortium members at Johns Hopkins that enroll patients in the PNRR. These include neuromuscular physicians Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Michael Polydefkis, Ricardo Roda, and Charlotte Sumner,
Publisher Copyright:
© 2020 Peripheral Nerve Society.
PY - 2020/12
Y1 - 2020/12
N2 - Although exercise is associated with better outcomes in patients with some peripheral neuropathies, data in idiopathic peripheral neuropathies is lacking. This study was completed to do a comprehensive data analysis about the benefits of regular exercise in a well-characterized cohort of patients with idiopathic distal, symmetrical, axonal polyneuropathy enrolled in the Peripheral Neuropathy Research Registry (PNRR) at Johns Hopkins University School of Medicine. From the patient-reported exercise habits, metabolic equivalents (METs) were calculated and the patient information was grouped into four categories. The PNRR data set, including patient reported pain, numbness, and weakness, was analyzed using the METs categories to evaluate for the benefits of exercise. We controlled for the components of metabolic syndrome including Hemoglobin A1c (HbA1c), systolic and diastolic blood pressure (BP), high density lipids (HDL) and triglyceride level, and body mass index (BMI) as defined by the Adult Treatment Panel III Guidelines. Lower METs were associated with neuropathic pain, but not with other peripheral neuropathy symptoms. Patients with IPN who exercised were less likely to have painful neuropathy independent of the average METs per week (P <.01). No significant differences were seen for patient reported numbness, weakness, or balance issues. The data suggests that patients with idiopathic neuropathy benefit from exercises even if performed on a low intensity level or less frequently, and patients are less likely to have severe pain symptoms when exercising on a regular basis.
AB - Although exercise is associated with better outcomes in patients with some peripheral neuropathies, data in idiopathic peripheral neuropathies is lacking. This study was completed to do a comprehensive data analysis about the benefits of regular exercise in a well-characterized cohort of patients with idiopathic distal, symmetrical, axonal polyneuropathy enrolled in the Peripheral Neuropathy Research Registry (PNRR) at Johns Hopkins University School of Medicine. From the patient-reported exercise habits, metabolic equivalents (METs) were calculated and the patient information was grouped into four categories. The PNRR data set, including patient reported pain, numbness, and weakness, was analyzed using the METs categories to evaluate for the benefits of exercise. We controlled for the components of metabolic syndrome including Hemoglobin A1c (HbA1c), systolic and diastolic blood pressure (BP), high density lipids (HDL) and triglyceride level, and body mass index (BMI) as defined by the Adult Treatment Panel III Guidelines. Lower METs were associated with neuropathic pain, but not with other peripheral neuropathy symptoms. Patients with IPN who exercised were less likely to have painful neuropathy independent of the average METs per week (P <.01). No significant differences were seen for patient reported numbness, weakness, or balance issues. The data suggests that patients with idiopathic neuropathy benefit from exercises even if performed on a low intensity level or less frequently, and patients are less likely to have severe pain symptoms when exercising on a regular basis.
KW - METs
KW - exercise
KW - idiopathic axonal peripheral neuropathy
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U2 - 10.1111/jns.12415
DO - 10.1111/jns.12415
M3 - Article
C2 - 33025680
AN - SCOPUS:85092344484
SN - 1085-9489
VL - 25
SP - 388
EP - 394
JO - Journal of the Peripheral Nervous System
JF - Journal of the Peripheral Nervous System
IS - 4
ER -