Relation of Electrocardiographic Left Atrial Abnormalities to Risk of Stroke in Patients with Atrial Fibrillation

Yuko Y. Inoue, Esra G. Ipek, Irfan M. Khurram, Luisa Ciuffo, Jonathan Chrispin, Stefan L. Zimmerman, Joseph E. Marine, John Rickard, David D. Spragg, Saman Nazarian, Kengo Kusano, Joao A. Lima, Ronald D. Berger, Hugh Calkins, Hiroshi Ashikaga

Research output: Contribution to journalArticlepeer-review


The P-wave terminal force in lead V1 (PTFV1) on the 12-lead electrocardiogram (ECG) quantifies left atrial (LA) structural and electrophysiologic abnormalities. We aimed to evaluate the association between PTFV1 and cerebrovascular accident (CVA) as well as LA structure and function in patients with atrial fibrillation (AF). We conducted a cross-sectional study of 229 patients with AF (60 ± 10years, 72% men) with (n = 21) and without (n = 208) a history of CVA, who underwent preablation ECG and cardiac magnetic resonance in sinus rhythm. PTFV1 was defined as the duration (in milliseconds) of the downward deflection of the P wave in lead V1 multiplied by the absolute value of its amplitude (in microvolts) on ECG. PTFV1 is associated with LA minimum volume (Vmin) and left ventricular ejection fraction but not associated with the extent of LA fibrosis quantified by cardiac magnetic resonance late gadolinium enhancement. In addition, PTFV1 is associated with CVA independent of the CHA2DS2-VASc score and LA Vmin (odds ratio 1.23; 95% confidence interval 1.08 to 1.40; p = 0.002). Furthermore, PTFV1 has an incremental value over the CHA2DS2-VASc score as a marker of CVA (p <0.001). In conclusion, ECG-defined PTFV1 is independent marker of stroke in patients with AF and reflects the underlying LA remodeling. Our findings suggest that evaluation of PTFV1 can improve the current risk stratification of stroke.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalAmerican Journal of Cardiology
Issue number2
StatePublished - Jul 15 2018

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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