Relation of EEG alpha background to parietal lobe function in Alzheimer’s disease as measured by positron emission tomography and psychometry

P. H. Sheridan, S. Sato, N. Foster, G. Bruno, C. Cox, P. Fedio, T. N. Chase

    Research output: Contribution to journalArticle

    Abstract

    Fourteen patients with Alzheimer’s disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha backgrounds. Group A had significantly higher WAIS Performance IQ scores (p = 0.005) than group B. Group A also had higher Weschler Memory Scale scores (p = 0.047) and parietal glucose metabolic rates (p = 0.038) than group B, but these differences are not statistically significant given the multiple comparisons made between the two groups. Relative intactness of parietal lobe function, as measured by psychometric testing and PET, appears to correlate with preservation of EEG alpha background. The EEG may be useful in assessing regional cortical involvement or the clinical stage in Alzheimer’s disease.

    Original languageEnglish (US)
    Pages (from-to)747-750
    Number of pages4
    JournalNeurology
    Volume38
    Issue number5
    DOIs
    StatePublished - May 1988

    ASJC Scopus subject areas

    • Clinical Neurology

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