TY - JOUR
T1 - Relation of diurnal blood pressure variation and triglyceride-to-high- density lipoprotein cholesterol ratio in patients without diabetes mellitus
AU - Davidson, Michael B.
AU - Vidt, Donald G.
AU - Hoogwerf, Byron J.
AU - Brotman, Daniel J.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - A night-time decrease in systolic blood pressure that differs <10% from mean daytime values ("nondipping") is associated with increased rates of cardiovascular morbidity and mortality. We hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension. We included 106 consecutive outpatients who had been referred for 24-hour ambulatory monitoring of blood pressure. Our data suggest that insulin resistance, defined as a high ratio of triglyceride to high-density lipoprotein, is associated with blunted diurnal blood pressure variation (odds ratio 6.3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose.
AB - A night-time decrease in systolic blood pressure that differs <10% from mean daytime values ("nondipping") is associated with increased rates of cardiovascular morbidity and mortality. We hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension. We included 106 consecutive outpatients who had been referred for 24-hour ambulatory monitoring of blood pressure. Our data suggest that insulin resistance, defined as a high ratio of triglyceride to high-density lipoprotein, is associated with blunted diurnal blood pressure variation (odds ratio 6.3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose.
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U2 - 10.1016/j.amjcard.2004.08.077
DO - 10.1016/j.amjcard.2004.08.077
M3 - Article
C2 - 15619409
AN - SCOPUS:11144227668
SN - 0002-9149
VL - 95
SP - 123
EP - 126
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 1
ER -