Relation of diurnal blood pressure variation and triglyceride-to-high- density lipoprotein cholesterol ratio in patients without diabetes mellitus

Michael B. Davidson, Donald G. Vidt, Byron J. Hoogwerf, Daniel J. Brotman

Research output: Contribution to journalArticlepeer-review

Abstract

A night-time decrease in systolic blood pressure that differs <10% from mean daytime values ("nondipping") is associated with increased rates of cardiovascular morbidity and mortality. We hypothesized that insulin resistance would be associated with nondipping in patients who did not have frank diabetes mellitus or hypertension. We included 106 consecutive outpatients who had been referred for 24-hour ambulatory monitoring of blood pressure. Our data suggest that insulin resistance, defined as a high ratio of triglyceride to high-density lipoprotein, is associated with blunted diurnal blood pressure variation (odds ratio 6.3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalAmerican Journal of Cardiology
Volume95
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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