Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma

Jeffrey M. Trent, Frank L. Meyskens, Sydney E. Salmon, Kay Ryschon, Stanley P.l. Leong, John R. Davis, Daniel L. Mcgee

Research output: Contribution to journalArticlepeer-review


The value of chromosomal analysis is well established in human hematologic neoplasms. In contrast, the relation between chromosomal abnormalities and clinical outcome in solid tumors in humans has received little study. We undertook this study to determine whether chromosomal abnormalities could provide information on the survival of patients with malignant melanoma. Chromosome-banding analysis was performed on tumor-biopsy samples from 62 patients with metastatic melanoma, and recurring cytogenetic abnormalities were correlated with survival. Patients with structural abnormalities of chromosome 7 or 11 had significantly shorter survival than patients without these abnormalities. We conclude that cytogenetic analysis may provide useful prognostic information about patients with metastatic melanoma. (N Engl J Med 1990; 322:1508–11.).

Original languageEnglish (US)
Pages (from-to)1508-1511
Number of pages4
JournalNew England Journal of Medicine
Issue number21
StatePublished - May 24 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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