Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma

Jeffrey M. Trent, Frank L. Meyskens, Sydney E. Salmon, Kay Ryschon, Stanley P L Leong, John R. Davis, Daniel L. Mcgee

Research output: Contribution to journalArticle

Abstract

The value of chromosomal analysis is well established in human hematologic neoplasms. In contrast, the relation between chromosomal abnormalities and clinical outcome in solid tumors in humans has received little study. We undertook this study to determine whether chromosomal abnormalities could provide information on the survival of patients with malignant melanoma. Chromosome-banding analysis was performed on tumor-biopsy samples from 62 patients with metastatic melanoma, and recurring cytogenetic abnormalities were correlated with survival. Patients with structural abnormalities of chromosome 7 or 11 had significantly shorter survival than patients without these abnormalities. We conclude that cytogenetic analysis may provide useful prognostic information about patients with metastatic melanoma.

Original languageEnglish (US)
Pages (from-to)1508-1511
Number of pages4
JournalNew England Journal of Medicine
Volume322
Issue number21
StatePublished - May 24 1990
Externally publishedYes

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Chromosome Aberrations
Melanoma
Survival
Chromosome Banding
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 7
Cytogenetic Analysis
Hematologic Neoplasms
Neoplasms
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Trent, J. M., Meyskens, F. L., Salmon, S. E., Ryschon, K., Leong, S. P. L., Davis, J. R., & Mcgee, D. L. (1990). Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. New England Journal of Medicine, 322(21), 1508-1511.

Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. / Trent, Jeffrey M.; Meyskens, Frank L.; Salmon, Sydney E.; Ryschon, Kay; Leong, Stanley P L; Davis, John R.; Mcgee, Daniel L.

In: New England Journal of Medicine, Vol. 322, No. 21, 24.05.1990, p. 1508-1511.

Research output: Contribution to journalArticle

Trent, JM, Meyskens, FL, Salmon, SE, Ryschon, K, Leong, SPL, Davis, JR & Mcgee, DL 1990, 'Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma', New England Journal of Medicine, vol. 322, no. 21, pp. 1508-1511.
Trent JM, Meyskens FL, Salmon SE, Ryschon K, Leong SPL, Davis JR et al. Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. New England Journal of Medicine. 1990 May 24;322(21):1508-1511.
Trent, Jeffrey M. ; Meyskens, Frank L. ; Salmon, Sydney E. ; Ryschon, Kay ; Leong, Stanley P L ; Davis, John R. ; Mcgee, Daniel L. / Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. In: New England Journal of Medicine. 1990 ; Vol. 322, No. 21. pp. 1508-1511.
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