Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens

Larry D. Bacon; Joseph H. Kite; Noel R. Rose

doi:10.1126/science.186.4160.274

Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens

Larry D. Bacon, Joseph H. Kite, Noel R. Rose

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61 Scopus citations

Abstract

Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B ¹ and B⁴, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B¹B¹ and B¹B⁴ birds than in their B⁴B⁴ siblings.

Original language	English (US)
Pages (from-to)	274-275
Number of pages	2
Journal	Science
Volume	186
Issue number	4160
DOIs	https://doi.org/10.1126/science.186.4160.274
State	Published - 1974
Externally published	Yes

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title = "Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens",

abstract = "Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B 1 and B4, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B1B1 and B1B4 birds than in their B4B4 siblings.",

author = "Bacon, {Larry D.} and Kite, {Joseph H.} and Rose, {Noel R.}",

year = "1974",

doi = "10.1126/science.186.4160.274",

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AU - Kite, Joseph H.

AU - Rose, Noel R.

PY - 1974

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N2 - Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B 1 and B4, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B1B1 and B1B4 birds than in their B4B4 siblings.

AB - Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B 1 and B4, are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B1B1 and B1B4 birds than in their B4B4 siblings.

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Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens

Abstract

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