Relation between ionized calcium concentration and ventricular pump performance in the dog under hemodynamically controlled conditions

Lambertus J. Drop, Gillian A. Geffin, Dennis D. O'Keefe, John B. Newell, Marshall L Jacobs, Burt N. Fowler, Willard M. Daggett, James S. Titus

Research output: Contribution to journalArticle

Abstract

The effect of plasma ionized calcium concentration on left ventricular function was studied in the canine heart on right heart bypass. Stroke volume, mean arterial pressure and heart rate were controlled. Plasma ionized calcium was lowered to 0.58 ± 0.01 mM by citrate infusion and raised to 1.70 ± 0.01 mM by calcium chloride infusion in random order in each dog. Left ventricular function at each of these ionized calcium levels was compared with that in an immediately preceding normocalcemic period. At a constant stroke work (16.9 ± 0.2 g-m), sustained hypercalcemia was associated with a small decrease in left ventricular end-diastolic pressure (1.7 ± 0.7 cm H2O, p 2O, by interpolation in left ventricular function curves, was 11 ± 4.4 percent above that at control normocalcemia (p 2O, p 2O was 52 ± 5.4 percent below control level (p

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalThe American Journal of Cardiology
Volume47
Issue number5
DOIs
StatePublished - 1981
Externally publishedYes

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Left Ventricular Function
Dogs
Calcium
Right Heart Bypass
Calcium Chloride
Hypercalcemia
Citric Acid
Stroke Volume
Canidae
Arterial Pressure
Heart Rate
Stroke
Blood Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Relation between ionized calcium concentration and ventricular pump performance in the dog under hemodynamically controlled conditions. / Drop, Lambertus J.; Geffin, Gillian A.; O'Keefe, Dennis D.; Newell, John B.; Jacobs, Marshall L; Fowler, Burt N.; Daggett, Willard M.; Titus, James S.

In: The American Journal of Cardiology, Vol. 47, No. 5, 1981, p. 1041-1051.

Research output: Contribution to journalArticle

Drop, Lambertus J. ; Geffin, Gillian A. ; O'Keefe, Dennis D. ; Newell, John B. ; Jacobs, Marshall L ; Fowler, Burt N. ; Daggett, Willard M. ; Titus, James S. / Relation between ionized calcium concentration and ventricular pump performance in the dog under hemodynamically controlled conditions. In: The American Journal of Cardiology. 1981 ; Vol. 47, No. 5. pp. 1041-1051.
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