Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] study)

Harjit Chahal, Jye Yu C Backlund, Patricia A. Cleary, John M. Lachin, Joseph F. Polak, Joao Lima, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Type 1 diabetes mellitus (DM) is associated with early atherosclerosis and increased cardiovascular mortality. The relation between carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, and left ventricular (LV) mass, an independent predictor of cardiovascular morbidity, has not been previously studied in type 1 DM. The Epidemiology of Diabetes Interventions and Complications (EDIC) study is a multicenter observational study designed to follow up the Diabetes Control and Complications Trial (DCCT) cohort. LV mass was measured with cardiac magnetic resonance imaging at EDIC year 15 and common cIMT was assessed using B-mode ultrasound at EDIC year 12. Multivariable linear regression models were used to assess the relation between cIMT at year 12 and LV mass at year 15. In total 889 participants had cardiac magnetic resonance imaging and cIMT measurements available for these analyses. At EDIC year 15, mean age of the participants was 49 ± 7 years, mean DM duration was 28 ± 5 years, and 52% were men. Spearman correlation coefficient (r) between LV mass and cIMT was 0.33 (p 2 per 0.1-mm cIMT increment, p 2 per 0.1-mm cIMT increment (p

Original languageEnglish (US)
Pages (from-to)1534-1540
Number of pages7
JournalThe American Journal of Cardiology
Volume110
Issue number10
DOIs
StatePublished - Nov 15 2012

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Carotid Intima-Media Thickness
Diabetes Complications
Type 1 Diabetes Mellitus
Epidemiology
Linear Models
Atherosclerosis
Magnetic Resonance Imaging
Multicenter Studies
Observational Studies
Diabetes Mellitus
Morbidity
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] study). / Chahal, Harjit; Backlund, Jye Yu C; Cleary, Patricia A.; Lachin, John M.; Polak, Joseph F.; Lima, Joao; Bluemke, David A.

In: The American Journal of Cardiology, Vol. 110, No. 10, 15.11.2012, p. 1534-1540.

Research output: Contribution to journalArticle

Chahal, Harjit ; Backlund, Jye Yu C ; Cleary, Patricia A. ; Lachin, John M. ; Polak, Joseph F. ; Lima, Joao ; Bluemke, David A. / Relation between carotid intima-media thickness and left ventricular mass in type 1 diabetes mellitus (from the Epidemiology of Diabetes Interventions and Complications [EDIC] study). In: The American Journal of Cardiology. 2012 ; Vol. 110, No. 10. pp. 1534-1540.
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