Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome

Maire E. Percy, Zoya Potyomkina, Arthur J. Dalton, Bettye Fedor, Pankaj Mehta, David F. Andrews, Tony Mazzulli, Lillian Murk, Andrew C. Warren, Robyn A. Wallace, Hien Chau, Winnie Jeng, Sharon Moalem, Lisa O'Brien, Sonia Schellenberger, Helen Tran, Linda Wu

Research output: Contribution to journalArticle

Abstract

Dementia of the Alzheimer type (DAT) is common in older persons with Down syndrome (DS). There are three common alleles of the apolipoprotein E (ApoE) gene (Σ2, Σ3, and Σ4) resulting in three different isoforms (E2, E3, and E4) and six different genotypes (2,2; 2,3; 2,4; 3,3; 3,4; and 4,4). Σ4 is a risk factor for DAT whereas Σ2 appears prophylactic. As hepatitis B virus (HBV) infection and hypothyroidism also are common in DS, we evaluated associations between ApoE type, HBV status, and thyroid status in a sample of older persons with DS (n = 55; mean age, 44.3 ± 10.8 years) using chi-squared analysis. Participants were classified as E2 (2,2 or 2,3), E3 (3,3), or E4 (3,4 or 4,4); positive for markers of HBV infection in the present or past (i.e., total HBcAb+ and/or HBsAg+ with or without infectivity, defined as HBV+) or negative for markers of HBV infection (defined as HBV-) and, currently receiving thyroid hormone supplement (defined as " hypothyroidism") or having normal thyroid function. The majority of the HBV+ were currently HBcAb+ and HBsAb+, but not HBsAg+. In females, there was an ApoE allele effect on thyroid status (P ≤ 0.01), E2 being negatively (P ≤ 0.01) and E4 being positively (P ≤ 0.05) associated with " hypothyroidism". There was no evidence for an ApoE allele effect on thyroid status in males. There was no evidence for an ApoE allele effect on HBV status, or for an HBV status effect on thyroid status. As thyroid status can affect cognitive function, ApoE allele effects in DAT may, in part, be thyroid effects.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume120 A
Issue number2
StatePublished - Jul 15 2003

Fingerprint

Apolipoproteins E
Down Syndrome
Hepatitis B virus
Thyroid Gland
Genotype
Alleles
Virus Diseases
Hypothyroidism
Alzheimer Disease
Hepatitis B Surface Antigens
Apolipoprotein E2
Human Herpesvirus 4
Thyroid Hormones
Cognition
Protein Isoforms

Keywords

  • Apolipoprotein E
  • Down syndrome
  • Hepatitis B virus
  • Thyroid abnormality

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Percy, M. E., Potyomkina, Z., Dalton, A. J., Fedor, B., Mehta, P., Andrews, D. F., ... Wu, L. (2003). Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome. American Journal of Medical Genetics, 120 A(2), 191-198.

Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome. / Percy, Maire E.; Potyomkina, Zoya; Dalton, Arthur J.; Fedor, Bettye; Mehta, Pankaj; Andrews, David F.; Mazzulli, Tony; Murk, Lillian; Warren, Andrew C.; Wallace, Robyn A.; Chau, Hien; Jeng, Winnie; Moalem, Sharon; O'Brien, Lisa; Schellenberger, Sonia; Tran, Helen; Wu, Linda.

In: American Journal of Medical Genetics, Vol. 120 A, No. 2, 15.07.2003, p. 191-198.

Research output: Contribution to journalArticle

Percy, ME, Potyomkina, Z, Dalton, AJ, Fedor, B, Mehta, P, Andrews, DF, Mazzulli, T, Murk, L, Warren, AC, Wallace, RA, Chau, H, Jeng, W, Moalem, S, O'Brien, L, Schellenberger, S, Tran, H & Wu, L 2003, 'Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome', American Journal of Medical Genetics, vol. 120 A, no. 2, pp. 191-198.
Percy, Maire E. ; Potyomkina, Zoya ; Dalton, Arthur J. ; Fedor, Bettye ; Mehta, Pankaj ; Andrews, David F. ; Mazzulli, Tony ; Murk, Lillian ; Warren, Andrew C. ; Wallace, Robyn A. ; Chau, Hien ; Jeng, Winnie ; Moalem, Sharon ; O'Brien, Lisa ; Schellenberger, Sonia ; Tran, Helen ; Wu, Linda. / Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome. In: American Journal of Medical Genetics. 2003 ; Vol. 120 A, No. 2. pp. 191-198.
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abstract = "Dementia of the Alzheimer type (DAT) is common in older persons with Down syndrome (DS). There are three common alleles of the apolipoprotein E (ApoE) gene (Σ2, Σ3, and Σ4) resulting in three different isoforms (E2, E3, and E4) and six different genotypes (2,2; 2,3; 2,4; 3,3; 3,4; and 4,4). Σ4 is a risk factor for DAT whereas Σ2 appears prophylactic. As hepatitis B virus (HBV) infection and hypothyroidism also are common in DS, we evaluated associations between ApoE type, HBV status, and thyroid status in a sample of older persons with DS (n = 55; mean age, 44.3 ± 10.8 years) using chi-squared analysis. Participants were classified as E2 (2,2 or 2,3), E3 (3,3), or E4 (3,4 or 4,4); positive for markers of HBV infection in the present or past (i.e., total HBcAb+ and/or HBsAg+ with or without infectivity, defined as HBV+) or negative for markers of HBV infection (defined as HBV-) and, currently receiving thyroid hormone supplement (defined as {"} hypothyroidism{"}) or having normal thyroid function. The majority of the HBV+ were currently HBcAb+ and HBsAb+, but not HBsAg+. In females, there was an ApoE allele effect on thyroid status (P ≤ 0.01), E2 being negatively (P ≤ 0.01) and E4 being positively (P ≤ 0.05) associated with {"} hypothyroidism{"}. There was no evidence for an ApoE allele effect on thyroid status in males. There was no evidence for an ApoE allele effect on HBV status, or for an HBV status effect on thyroid status. As thyroid status can affect cognitive function, ApoE allele effects in DAT may, in part, be thyroid effects.",
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