Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

Susanne Liptay; Roland M. Schmid; Neil D. Perkins; Paul Meltzer; Michael R. Altherr; John D. McPherson; John J. Wasmuth; Gary J. Nabel

doi:10.1016/0888-7543(92)90244-M

Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

Susanne Liptay, Roland M. Schmid, Neil D. Perkins, Paul Meltzer, Michael R. Altherr, John D. McPherson, John J. Wasmuth, Gary J. Nabel

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-κB complex, p105 and p49 p100, respectively, have been determined. p105 was assigned to 4q21.1-q24 and p49 p100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and 10q24, respectively. These results demonstrate that these members of the NF-κB family are unlinked. Interestingly, p49 p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.

Original language	English (US)
Pages (from-to)	287-292
Number of pages	6
Journal	Genomics
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0888-7543(92)90244-M
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/0888-7543(92)90244-M

Cite this

@article{949785f720f54f7f850db2c74c42074f,

title = "Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2",

abstract = "The chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-κB complex, p105 and p49 p100, respectively, have been determined. p105 was assigned to 4q21.1-q24 and p49 p100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and 10q24, respectively. These results demonstrate that these members of the NF-κB family are unlinked. Interestingly, p49 p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.",

author = "Susanne Liptay and Schmid, {Roland M.} and Perkins, {Neil D.} and Paul Meltzer and Altherr, {Michael R.} and McPherson, {John D.} and Wasmuth, {John J.} and Nabel, {Gary J.}",

year = "1992",

doi = "10.1016/0888-7543(92)90244-M",

language = "English (US)",

volume = "13",

pages = "287--292",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

AU - Liptay, Susanne

AU - Schmid, Roland M.

AU - Perkins, Neil D.

AU - Meltzer, Paul

AU - Altherr, Michael R.

AU - McPherson, John D.

AU - Wasmuth, John J.

AU - Nabel, Gary J.

PY - 1992

Y1 - 1992

N2 - The chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-κB complex, p105 and p49 p100, respectively, have been determined. p105 was assigned to 4q21.1-q24 and p49 p100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and 10q24, respectively. These results demonstrate that these members of the NF-κB family are unlinked. Interestingly, p49 p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.

AB - The chromosomal locations of the human genes NFKB1 and NFKB2, which encode two alternative DNA binding subunits of the NF-κB complex, p105 and p49 p100, respectively, have been determined. p105 was assigned to 4q21.1-q24 and p49 p100 to chromosome 10 by Southern blot analysis of panels of human/Chinese hamster cell hybrids. The locations were confirmed by fluorescence in situ hybridization and mapped with greater resolution to 4q23 and 10q24, respectively. These results demonstrate that these members of the NF-κB family are unlinked. Interestingly, p49 p100 as well as p105 maps to regions associated with certain types of acute lymphoblastic leukemia.

UR - http://www.scopus.com/inward/record.url?scp=0026636897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026636897&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(92)90244-M

DO - 10.1016/0888-7543(92)90244-M

M3 - Article

C2 - 1612589

AN - SCOPUS:0026636897

SN - 0888-7543

VL - 13

SP - 287

EP - 292

JO - Genomics

JF - Genomics

IS - 2

ER -

Related subunits of NF-κB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this