Relapse: Surgical considerations and secondary cytoreduction

Sara M. Jordan, Robert E. Bristow

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter focuses on the survival bene fi t, selection criteria, and morbidity and mortality associated with secondary cytoreduction for recurrent ovarian cancer in the general population and the elderly. The goal of secondary cytoreduction is to improve overall survival by maximizing surgical tumor eradication in patients who demonstrate a complete clinical response to initial platinum-based chemotherapy. Retrospective studies consistently demonstrate a survival bene fi t associated with maximal secondary cytoreduction. Patient selection criteria should be individualized based on the patient's life goals, comorbidities and performance status, and availability of adjuvant therapy. Morbidity and mortality rates are comparable to those associated with primary cytoreduction. The role of secondary cytoreduction in the geriatric population is still evolving. In general, elderly are less likely to receive standard treatment for ovarian cancer, but research suggests that secondary cytoreduction can be both safe and feasible and advanced age alone should not be a contraindication to surgery.

Original languageEnglish (US)
Title of host publicationManagement of Gynecological Cancers in Older Women
PublisherSpringer-Verlag London Ltd
Pages183-198
Number of pages16
ISBN (Electronic)9781447146056
ISBN (Print)9781447122159
DOIs
StatePublished - Jan 1 2013

Keywords

  • Elderly
  • Recurrent epithelial ovarian cancer
  • Relapse
  • Secondary cytoreduction
  • Secondary cytoreductive surgery

ASJC Scopus subject areas

  • Medicine(all)

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