Reinforcing, subjective, and performance effects of lorazepam and diphenhydramine in humans

Research output: Contribution to journalArticle

Abstract

The reinforcing, subjective, and performance effects of 400 mg diphenhydramine (D), 4 mg lorazepam (L), and placebo (P) were compared across repeated administrations in 12 healthy, adult male participants with histories of recreational sedative abuse. P, L, and D were administered orally in a block, random sequence 4 times each. L and D increased scores on participants' liking of the drug, desire to take the drug again, and monetary value of the drug relative to placebo. D increased ratings on scales of unpleasant somatic side effects. When the choice was between D and P or between L and P, choice between D and L was greater than chance, and choice of P was less than chance. When the choice was between D and L, both drugs were chosen an equal number of times. L and D effects were consistent across repeated administrations. Correlational analysis showed that some subjective measures were positively correlated, whereas other measures were negatively correlated with measures of drug reinforcement.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalExperimental and clinical psychopharmacology
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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