Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys

Michael R. Weed, Kimberly E. Vanover, William L. Woolverton

Research output: Contribution to journalArticle

Abstract

Rhesus monkeys with IV catheters were allowed to self-administer cocaine for 1 h/day. When responding was stable, saline or the D1 dopamine agonist SKF 81297 (SKF; 0.001-0.3 mg/kg/inj) was substituted for cocaine. At least two doses of SKF maintained responding above saline levels in all monkeys. The D1 antagonist SCH 39166 (0.001-0.03 mg/kg, IM) was then administered 30 min before sessions of self-administration of the lowest dose of SKF that maintained behavior (0.01 mg/kg/inj). SKF-maintained responding decreased in a dose-related manner, suggesting antagonism of the reinforcing effect. These results suggest that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.

Original languageEnglish (US)
Pages (from-to)51-52
Number of pages2
JournalPsychopharmacology
Volume113
Issue number1
DOIs
StatePublished - Nov 1 1993

Keywords

  • D receptors
  • Dopamine
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology

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