Rehmannia inhibits adipocyte differentiation and adipogenesis

Lin Jiang, Nai xian Zhang, Wei Mo, Rui Wan, Chun gu Ma, Xi Li, Yin liang Gu, Xin Ying Yang, Qi qun Tang, Hou yan Song

Research output: Contribution to journalArticlepeer-review

Abstract

Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPβ, as well as C/EBPα and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPβ to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume371
Issue number2
DOIs
StatePublished - Jun 27 2008
Externally publishedYes

Keywords

  • 3T3-L1
  • Adipocyte differentiation
  • Adipogenesis
  • Rehmannia glutinosa

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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