Rehmannia inhibits adipocyte differentiation and adipogenesis

Lin Jiang; Nai xian Zhang; Wei Mo; Rui Wan; Chun gu Ma; Xi Li; Yin liang Gu; Xin Ying Yang; Qi qun Tang; Hou yan Song

doi:10.1016/j.bbrc.2008.03.129

Rehmannia inhibits adipocyte differentiation and adipogenesis

Lin Jiang, Nai xian Zhang, Wei Mo, Rui Wan, Chun gu Ma, Xi Li, Yin liang Gu, Xin Ying Yang, Qi qun Tang, Hou yan Song

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPβ, as well as C/EBPα and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPβ to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.

Original language	English (US)
Pages (from-to)	185-190
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	371
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2008.03.129
State	Published - Jun 27 2008
Externally published	Yes

Keywords

3T3-L1
Adipocyte differentiation
Adipogenesis
Rehmannia glutinosa

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/j.bbrc.2008.03.129

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title = "Rehmannia inhibits adipocyte differentiation and adipogenesis",

abstract = "Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPβ, as well as C/EBPα and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPβ to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.",

keywords = "3T3-L1, Adipocyte differentiation, Adipogenesis, Rehmannia glutinosa",

author = "Lin Jiang and Zhang, {Nai xian} and Wei Mo and Rui Wan and Ma, {Chun gu} and Xi Li and Gu, {Yin liang} and Yang, {Xin Ying} and Tang, {Qi qun} and Song, {Hou yan}",

year = "2008",

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doi = "10.1016/j.bbrc.2008.03.129",

language = "English (US)",

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T1 - Rehmannia inhibits adipocyte differentiation and adipogenesis

AU - Jiang, Lin

AU - Zhang, Nai xian

AU - Mo, Wei

AU - Wan, Rui

AU - Ma, Chun gu

AU - Li, Xi

AU - Gu, Yin liang

AU - Yang, Xin Ying

AU - Tang, Qi qun

AU - Song, Hou yan

PY - 2008/6/27

Y1 - 2008/6/27

N2 - Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPβ, as well as C/EBPα and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPβ to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.

AB - Rehmannia glutinosa, a Traditional Chinese Medicine (TCM), has been used to increase physical strength. Here, we report that Rehmannia glutinosa extract (RE) inhibits adipocyte differentiation and adipogenesis. RE impairs differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. At the molecular level, treatment with RE inhibits expression of the key adipocyte differentiation regulator C/EBPβ, as well as C/EBPα and the terminal marker protein 422/aP2, during differentiation of preadipocytes into adipocytes. Additionally, RE inhibits the mitotic clonal expansion (MCE) process of adipocyte differentiation, and RE prevents localization of C/EBPβ to the centromeres. RE also prevents high fat diet (HFD) induced weight gain and adiposity in rats. Taken together, our results indicate that Rehmannia glutinosa extract inhibits preadipocyte differentiation and adipogenesis in cultured cells and in rodent models of obesity.

KW - 3T3-L1

KW - Adipocyte differentiation

KW - Adipogenesis

KW - Rehmannia glutinosa

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Rehmannia inhibits adipocyte differentiation and adipogenesis

Abstract

Keywords

ASJC Scopus subject areas

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