TY - JOUR
T1 - Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity
T2 - Systematic review and evidence-based recommendations
AU - on behalf of the Toxic Neuropathy Consortium
AU - Tamburin, Stefano
AU - Park, Susanna B.
AU - Schenone, Angelo
AU - Mantovani, Elisa
AU - Hamedani, Mehrnaz
AU - Alberti, Paola
AU - Yildiz-Kabak, Vesile
AU - Kleckner, Ian R.
AU - Kolb, Noah
AU - Mazzucchelli, Miryam
AU - McNeish, Brendan L.
AU - Argyriou, Andreas A.
AU - Cavaletti, Guido
AU - Hoke, Ahmet
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022/3
Y1 - 2022/3
N2 - Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.
AB - Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.
KW - Chemotherapy-induced peripheral neurotoxicity (CIPN)
KW - Evidence-based medicine
KW - Exercise
KW - Physical therapy
KW - Rehabilitation
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85122700225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122700225&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2021.103575
DO - 10.1016/j.critrevonc.2021.103575
M3 - Review article
C2 - 34968623
AN - SCOPUS:85122700225
SN - 1040-8428
VL - 171
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103575
ER -