Regulatory T cells and the pursuit of self-tolerance

Allan D. Hess

Research output: Contribution to journalReview articlepeer-review

Abstract

Failure of the CD4+CD25+Foxp3+ regulatory T-cell compartment to control immune reactivity to self-antigens leads to the development of chronic graft-versus-host disease largely mediated by donor-derived helper T cells that secrete proinflammatory cytokines.

Original languageEnglish (US)
Pages (from-to)3497-3498
Number of pages2
JournalBlood
Volume110
Issue number10
DOIs
StatePublished - Nov 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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