Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum

K. Gronstad, A. Dahlstrom, L. Florence, M. J. Zinner, J. Ahlman, B. M. Jaffe

Research output: Contribution to journalArticle

Abstract

The mechanisms controlling vagally induced 5-HT and SP release into the jejunal lumen were studied in the cat. In control animals, electrical vagal nerve stimulation doubled the rate of endoluminal secretion of 5-HT and SP. Propranolol pretreatment did not alter luminal secretion of these hormones. Atropine suppressed motor function and induced dose-related inhibition of vagal release of endoluminal 5-HT, but not of SP; the response to hexamethonium pretreatment was similar to that of atropine. In contrast, superior cervical ganglionectomy did not alter stimulated endoluminal 5-HT release but it completely abolished release into the portal vein. The portal 5-HT release was not affected by ganglionic blockade. The data suggest that (1) vagally mediated 5-HT release into the lumen and the portal circulation are mediated by different neural mechanisms, the former cholinergic, the latter presumably adrenergic; and (2) release of feline 5-HT and SP are independent, suggesting two intestinal sources, the EC cell for 5-HT and peptidergic neurons for SP.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalDigestive Diseases and Sciences
Volume32
Issue number4
DOIs
StatePublished - Apr 1987
Externally publishedYes

Fingerprint

Felidae
Jejunum
Substance P
Serotonin
Atropine
Ganglionectomy
Vagus Nerve Stimulation
Hexamethonium
Portal Vein
Propranolol
Adrenergic Agents
Cholinergic Agents
Cats
Hormones
Neurons

Keywords

  • adrenergic
  • cholinergic
  • endoluminal release
  • serotonin
  • substance P

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Gronstad, K., Dahlstrom, A., Florence, L., Zinner, M. J., Ahlman, J., & Jaffe, B. M. (1987). Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum. Digestive Diseases and Sciences, 32(4), 393-400. https://doi.org/10.1007/BF01296293

Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum. / Gronstad, K.; Dahlstrom, A.; Florence, L.; Zinner, M. J.; Ahlman, J.; Jaffe, B. M.

In: Digestive Diseases and Sciences, Vol. 32, No. 4, 04.1987, p. 393-400.

Research output: Contribution to journalArticle

Gronstad, K, Dahlstrom, A, Florence, L, Zinner, MJ, Ahlman, J & Jaffe, BM 1987, 'Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum', Digestive Diseases and Sciences, vol. 32, no. 4, pp. 393-400. https://doi.org/10.1007/BF01296293
Gronstad, K. ; Dahlstrom, A. ; Florence, L. ; Zinner, M. J. ; Ahlman, J. ; Jaffe, B. M. / Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum. In: Digestive Diseases and Sciences. 1987 ; Vol. 32, No. 4. pp. 393-400.
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