Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease

Implications for etiology and therapy

T. A. Slotkin, F. J. Seidler, B. J. Crain, J. M. Bell, G. Bissette, C. B. Nemeroff

Research output: Contribution to journalArticle

Abstract

Brain regions from patients with or without Alzheimer disease (AD) were obtained within 2 hr of death and examined for indices of presynaptic cholinergic function. Consistent with loss of cholinergic projections, cerebral cortical areas involved in AD exhibited decreased choline acetyltransferase (acetyl-CoA:choline 0-acetyltransferase, EC 2.3.1.6) activity. However, remaining nerve terminals in these regions displayed marked up-regulation of synaptosomal high affinity [3H]choline uptake, a result indicative of relative cholinergic hyperactivity. As choline uptake is also rate-limiting in acetylcholine biosynthesis, these findings have implications for both therapy and identification of causes contributing to neuronal death in AD.

Original languageEnglish (US)
Pages (from-to)2452-2455
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number7
StatePublished - Apr 1990
Externally publishedYes

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Choline O-Acetyltransferase
Cholinergic Agents
Autopsy
Alzheimer Disease
Choline
Acetyl Coenzyme A
Acetylcholine
Up-Regulation
Therapeutics
Brain

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease : Implications for etiology and therapy. / Slotkin, T. A.; Seidler, F. J.; Crain, B. J.; Bell, J. M.; Bissette, G.; Nemeroff, C. B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 7, 04.1990, p. 2452-2455.

Research output: Contribution to journalArticle

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