TY - JOUR
T1 - Regulatory binding partners and complexes of NHE3
AU - Donowitz, Mark
AU - Li, Xuhang
PY - 2007/7
Y1 - 2007/7
N2 - NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a highly regulated transporter, being both stimulated and inhibited by signaling that mimics the postprandial state. It also undergoes downregulation in diarrheal diseases as well as changes in renal disorders. For this regulation, NHE3 exists in large, multiprotein complexes in which it associates with at least nine other proteins. This review deals with short-term regulation of NHE3 and the identity and function of its recognized interacting partners and the multiprotein complexes in which NHE3 functions.
AB - NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a highly regulated transporter, being both stimulated and inhibited by signaling that mimics the postprandial state. It also undergoes downregulation in diarrheal diseases as well as changes in renal disorders. For this regulation, NHE3 exists in large, multiprotein complexes in which it associates with at least nine other proteins. This review deals with short-term regulation of NHE3 and the identity and function of its recognized interacting partners and the multiprotein complexes in which NHE3 functions.
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U2 - 10.1152/physrev.00030.2006
DO - 10.1152/physrev.00030.2006
M3 - Review article
C2 - 17615390
AN - SCOPUS:34447629085
SN - 0031-9333
VL - 87
SP - 825
EP - 872
JO - Physiological reviews
JF - Physiological reviews
IS - 3
ER -