Regulation of Weibel-Palade body exocytosis

Charles J. Lowenstein, Craig N. Morrell, Munekazu Yamakuchi

Research output: Contribution to journalArticle

Abstract

Weibel-Palade bodies (WPBs) are endothelial granules that store von Willebrand factor (VWF), P-selectin, and other vascular modulators. Endothelial cells secrete WPBs in response to vascular injury, releasing VWF, which triggers platelet rolling, and externalizing P-selectin, which activates leukocyte trafficking. Endothelial exocytosis is one of the earliest responses to vascular damage and plays a pivotal role in thrombosis and inflammation. This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs.

Original languageEnglish (US)
Pages (from-to)302-308
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume15
Issue number8
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Lowenstein, C. J., Morrell, C. N., & Yamakuchi, M. (2005). Regulation of Weibel-Palade body exocytosis. Trends in Cardiovascular Medicine, 15(8), 302-308. https://doi.org/10.1016/j.tcm.2005.09.005