Regulation of tissue perfusion in mammals by hypoxia-inducible factor 1

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The regulation of tissue perfusion is a major mechanism by which oxygen homeostasis is maintained. Hypoxia-inducible factor 1 (HIF-1) is a transcriptional regulator that mediates adaptive responses to reduced partial pressure of O2 in all metazoan species. In mammals, HIF-1 promotes angiogenesis, arteriogenesis and vasculogenesis through the production of multiple angiogenic growth factors in ischaemic tissue and by cell-autonomous effects on endothelial cells and bone marrow-derived angiogenic cells. Administration of viral vectors encoding constitutively active forms of the HIF-1α subunit results in increased tissue perfusion in animal models of ischaemic cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)988-991
Number of pages4
JournalExperimental Physiology
Issue number6
StatePublished - Nov 2007

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)


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