Regulation of the proinflammatory effects of Fas ligand (CD95L)

Jian Jun Chen, Yongnian Sun, Gary J. Nabel

Research output: Contribution to journalArticlepeer-review

Abstract

Fas ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet in most tissues CD95L expression induces potent inflammatory responses. With a stably transfected colon carcinoma cell line, CT26-CD95L, the molecular basis for these divergent responses was defined. When injected subcutaneously, rejection of CT26-CD95L was caused by neutrophils activated by CD95L. CT26-CD95L survived in the intraocular space because of the presence of transforming growth factor-β (TGF-β), which inhibited neutrophil activation. Providing TGF-β to subcutaneous sites protected against tumor rejection. Thus, these cytokines together generate a microenvironment that promotes immunologic tolerance, which may aid in the amelioration of allograft rejection.

Original languageEnglish (US)
Pages (from-to)1714-1717
Number of pages4
JournalScience
Volume282
Issue number5394
StatePublished - Nov 27 1998
Externally publishedYes

ASJC Scopus subject areas

  • General

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