Regulation of the human immune response during tuberculosis

Jerrold J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary tuberculosis is characterized by depression of purified protein derivative-stimulated (PPD-stimulated) blastogenesis in peripheral blood mononuclear cells (PBMCs) as well as decreased production of interleukin-2 (IL-2) and interferon-γ, (IFN-γ). Circulating T cells and monocytes (MNs) are nonspecifically activated in situ. PPD directly stimulates the primed MNs from patients with tuberculosis (TB) to overproduce a panoply of cytokines including transforming growth factor-β (TGF-β) and IL-10, which serve to depress PPD-stimulated blastogenesis and cytokine expression. Cross-modulation by these immunosuppressive MN products is superimposed on a primary T cell abnormality that persists for at least 12 months after the diagnosis of TB and involves apoptotic mechanisms.

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume130
Issue number5
StatePublished - Nov 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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