Regulation of sexual development of Plasmodium by translational repression

Gunnar R. Mair; Joanna A.M. Braks; Lindsey S. Garver; Joop C.A.G. Wiegant; Neil Hall; Roeland W. Dirks; Shahid M. Khan; George Dimopoulos; Chris J. Janse; Andrew P. Waters

doi:10.1126/science.1125129

Regulation of sexual development of Plasmodium by translational repression

Gunnar R. Mair, Joanna A.M. Braks, Lindsey S. Garver, Joop C.A.G. Wiegant, Neil Hall, Roeland W. Dirks, Shahid M. Khan, George Dimopoulos, Chris J. Janse, Andrew P. Waters

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.

Original language	English (US)
Pages (from-to)	667-669
Number of pages	3
Journal	Science
Volume	313
Issue number	5787
DOIs	https://doi.org/10.1126/science.1125129
State	Published - Aug 4 2006

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title = "Regulation of sexual development of Plasmodium by translational repression",

abstract = "Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.",

author = "Mair, {Gunnar R.} and Braks, {Joanna A.M.} and Garver, {Lindsey S.} and Wiegant, {Joop C.A.G.} and Neil Hall and Dirks, {Roeland W.} and Khan, {Shahid M.} and George Dimopoulos and Janse, {Chris J.} and Waters, {Andrew P.}",

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AU - Mair, Gunnar R.

AU - Braks, Joanna A.M.

AU - Garver, Lindsey S.

AU - Wiegant, Joop C.A.G.

AU - Hall, Neil

AU - Dirks, Roeland W.

AU - Khan, Shahid M.

AU - Dimopoulos, George

AU - Janse, Chris J.

AU - Waters, Andrew P.

PY - 2006/8/4

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AB - Translational repression of messenger RNAs (mRNAs) plays an important role in sexual differentiation and gametogenesis in multicellular eukaryotes. Translational repression and mRNA turnover were shown to influence stage-specific gene expression in the protozoan Plasmodium. The DDX6-class RNA helicase, DOZI (development of zygote inhibited), is found in a complex with mRNA species in cytoplasmic bodies of female, blood-stage gametocytes. These translationally repressed complexes are normally stored for translation after fertilization. Genetic disruption of pbdozi inhibits the formation of the ribonucleoprotein complexes, and instead, at least 370 transcripts are diverted to a degradation pathway.

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Regulation of sexual development of Plasmodium by translational repression

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