Regulation of SATB1 during thymocyte development by TCR signaling

Kamalvishnu P. Gottimukkala, Rahul Jangid, Indumathi Patta, Dil Afroz Sultana, Archna Sharma, Jyoti Misra-Sen, Sanjeev Galande

Research output: Contribution to journalArticlepeer-review

Abstract

T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalMolecular Immunology
Volume77
DOIs
StatePublished - Sep 1 2016

Keywords

  • GATA-3
  • SATB1
  • Signaling
  • T cell receptor

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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