Regulation of SATB1 during thymocyte development by TCR signaling

Kamalvishnu P. Gottimukkala, Rahul Jangid, Indumathi Patta, Dil Afroz Sultana, Archna Sharma, Jyoti Misra-Sen, Sanjeev Galande

Research output: Contribution to journalArticle

Abstract

T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an array of transcription factors. In this study we show that special AT-rich binding protein 1 (SATB1), a T lineage-enriched chromatin organizer and regulator, is induced in response to TCR signaling during early thymocyte development. SATB1 expression profile coincides with T lineage commitment and upregulation of SATB1 correlates with positive selection of thymocytes. CD4 thymocytes exhibit a characteristic bimodal expression pattern that corresponds to immature and mature CD4 thymocytes. We also demonstrate that GATA3, the key transcriptional regulator of αβ T cells positively regulates SATB1 expression in thymocytes suggesting an important role for SATB1 during T cell development.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalMolecular Immunology
Volume77
DOIs
StatePublished - Sep 1 2016

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Thymocytes
T-Cell Antigen Receptor
Carrier Proteins
T-Lymphocytes
Thymus Gland
Chromatin
Transcription Factors
Up-Regulation

Keywords

  • GATA-3
  • SATB1
  • Signaling
  • T cell receptor

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this

Gottimukkala, K. P., Jangid, R., Patta, I., Sultana, D. A., Sharma, A., Misra-Sen, J., & Galande, S. (2016). Regulation of SATB1 during thymocyte development by TCR signaling. Molecular Immunology, 77, 34-43. https://doi.org/10.1016/j.molimm.2016.07.005

Regulation of SATB1 during thymocyte development by TCR signaling. / Gottimukkala, Kamalvishnu P.; Jangid, Rahul; Patta, Indumathi; Sultana, Dil Afroz; Sharma, Archna; Misra-Sen, Jyoti; Galande, Sanjeev.

In: Molecular Immunology, Vol. 77, 01.09.2016, p. 34-43.

Research output: Contribution to journalArticle

Gottimukkala, KP, Jangid, R, Patta, I, Sultana, DA, Sharma, A, Misra-Sen, J & Galande, S 2016, 'Regulation of SATB1 during thymocyte development by TCR signaling', Molecular Immunology, vol. 77, pp. 34-43. https://doi.org/10.1016/j.molimm.2016.07.005
Gottimukkala KP, Jangid R, Patta I, Sultana DA, Sharma A, Misra-Sen J et al. Regulation of SATB1 during thymocyte development by TCR signaling. Molecular Immunology. 2016 Sep 1;77:34-43. https://doi.org/10.1016/j.molimm.2016.07.005
Gottimukkala, Kamalvishnu P. ; Jangid, Rahul ; Patta, Indumathi ; Sultana, Dil Afroz ; Sharma, Archna ; Misra-Sen, Jyoti ; Galande, Sanjeev. / Regulation of SATB1 during thymocyte development by TCR signaling. In: Molecular Immunology. 2016 ; Vol. 77. pp. 34-43.
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