Regulation of rat magnocellular neurosecretory system by D-aspartate: Evidence for biological role(s) of a naturally occurring free D-amino acid in mammals

H. Wang, H. Wolosker, J. Pevsner, S. H. Snyder, D. J. Selkoe

Research output: Contribution to journalArticle

Abstract

Little evidence is available for the physiological function of D-amino acids in species other than bacteria. Here we demonstrate that naturally occurring free D-aspartate (D-Asp) is present in all magnocellular neurons of rat hypothalamus. The levels of this naturally occurring D-amino acid were elevated during lactation and returned to normal thereafter in the magnocellular neurosecretory system, which produces oxytocin, a hormone responsible for milk ejection during lactation. Intraperitoneal injections of D-Asp reproducibly increased oxytocin gene expression and decreased the concentration of circulating oxytocin in vivo. Similar changes were observed in the vasopressin system. These results provide evidence for the role(s) of naturally occurring free D-Asp in mammalian physiology. The findings argue against the conventional concept that only L-stereoisomers of amino acids are functional in higher species.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalJournal of Endocrinology
Volume167
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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