TY - JOUR
T1 - Regulation of pulsatile gonadotropin secretion in female reproductive pathophysiology
AU - Veldhuis, J. D.
AU - Evans, W. S.
AU - Johnson, M. L.
AU - Kolp, L. A.
PY - 1991
Y1 - 1991
N2 - Recent exciting developments in our understanding of control mechanisms in reproductive neuroendocrinology have fostered several significant new insights into the physiology of the normal human menstrual cycle, the mode of in vivo secretion of LH, the importance of biological and immunological LH activity, the regulation of the hypothalamic pulse generator by sex steroid hormones, and the control of gonadotropin production by GnRH. Important refinements in methodological techniques have also enhanced our concepts in neuroendocrine reproductive pathophysiology. Here, we will review one powerful analytical tool, deconvolution analysis, which allows a clinician and investigator to determine actual in vivo LH secretory rates and LH half-lives in individual subjects under specified treatment conditions (PNAS 84:7686-7690, 1987). Quantitative deconvolution unravels the plasma LH concentration profile into its constituent secretion and clearance components. Such studies have been applied to the normal human menstrual cycle and revealed that the LH secretory signal is subject to exquisite temporal regulation throughout the normal human menstrual cycle with menstrual stage-dependent changes in maximal LH secretory rate, LH secretory burst duration, the mass of LH secreted per burst, and the number of significant secretory events per 24 hr. This regulation of the secretory signal is specific, since the endogenous metabolic clearance rate for LH and its production rate do not vary.
AB - Recent exciting developments in our understanding of control mechanisms in reproductive neuroendocrinology have fostered several significant new insights into the physiology of the normal human menstrual cycle, the mode of in vivo secretion of LH, the importance of biological and immunological LH activity, the regulation of the hypothalamic pulse generator by sex steroid hormones, and the control of gonadotropin production by GnRH. Important refinements in methodological techniques have also enhanced our concepts in neuroendocrine reproductive pathophysiology. Here, we will review one powerful analytical tool, deconvolution analysis, which allows a clinician and investigator to determine actual in vivo LH secretory rates and LH half-lives in individual subjects under specified treatment conditions (PNAS 84:7686-7690, 1987). Quantitative deconvolution unravels the plasma LH concentration profile into its constituent secretion and clearance components. Such studies have been applied to the normal human menstrual cycle and revealed that the LH secretory signal is subject to exquisite temporal regulation throughout the normal human menstrual cycle with menstrual stage-dependent changes in maximal LH secretory rate, LH secretory burst duration, the mass of LH secreted per burst, and the number of significant secretory events per 24 hr. This regulation of the secretory signal is specific, since the endogenous metabolic clearance rate for LH and its production rate do not vary.
UR - http://www.scopus.com/inward/record.url?scp=0025951062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025951062&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0025951062
SN - 0393-5299
VL - 7
SP - 365
EP - 374
JO - New Trends in Gynaecology and Obstetrics
JF - New Trends in Gynaecology and Obstetrics
IS - 3-4
ER -