Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

Francisca Vazquez, Peter Devreotes

Research output: Contribution to journalReview article

Abstract

PTEN, one of the most frequently mutated genes in human cancer, acts as a tumor suppressor by dephosphorylating the plasma membrane lipid second messenger phosphoinositide-3,4,5-trisphosphate (PIP3) generated by the action of PI3Kinases. PTEN activity to prevent elevated levels of PIP3 and tumorigenesis depends on its interaction with the lipid bilayer. PTEN binds dynamically to the plasma membrane through a complex mix of protein-lipid and protein-protein interactions and the translocation is regulated by several mechanisms including C-terminal tail phosphorylations. Here we have summarized our current view of the interaction of PTEN with the plasma membrane and what the implications are for cancer biology.

Original languageEnglish (US)
Pages (from-to)1523-1527
Number of pages5
JournalCell Cycle
Volume5
Issue number14
DOIs
StatePublished - Jul 15 2006

Keywords

  • Cancer therapy
  • PI3K signaling
  • PTEN
  • Phosphorylation
  • Plasma membrane
  • Signal transduction
  • Tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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