Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis

L. Averill, Z. Toossi, H. Aung, W. H. Boom, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findings suggest that tumor necrosis factor alpha production may be up-regulated at both the posttranscriptional and transcriptional levels. Regulation at the posttranscriptional level probably reflects enhanced translational efficiency.

Original languageEnglish (US)
Pages (from-to)3206-3208
Number of pages3
JournalInfection and Immunity
Volume63
Issue number8
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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