Regulation of PML mRNA expression in human breast carcinoma cells

X. S. Li, M. S. Sheikh, Z. M. Shao, S. Lanzkron, J. C. Chen, J. A. Fontana

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the mRNA expression profile of PML, a novel nuclear protein recently characterized from acute promyelocytic leukemia (APL) blast cells, in a number of breast carcinoma cell lines. PML mRNA was found to be differentially expressed among the cell lines examined. A correlation of borderline significance between PML mRNA expression and the proliferative capacity of the cell lines was noted. Serum stimulation significantly elevated the PML mRNA levels in the T47D and MDA-MB-231 cells. These results would suggest that PML may function as a positive regulator of cellular proliferation in breast carcinoma cells.

Original languageEnglish (US)
Pages (from-to)1177-1181
Number of pages5
JournalInternational journal of oncology
Volume5
Issue number5
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Cell cycle
  • HBC
  • PML

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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