Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1

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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1α and HIF-1β subunits that functions as a master regulator of oxygen homeostasis. Oxygen-dependent hydroxylation of HIF-1α provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. Hypoxia-inducible factor 1 plays critical roles in development, physiology and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1α subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.

Original languageEnglish (US)
Pages (from-to)803-806
Number of pages4
JournalExperimental Physiology
Volume91
Issue number5
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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