TY - JOUR
T1 - Regulation of oxygen homeostasis by hypoxia-Inducible factor 1
AU - Semenza, Gregg L
PY - 2009/4
Y1 - 2009/4
N2 - Metazoan organisms are dependent on a continuous supply of O 2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca 2+ signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogram- ming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively.
AB - Metazoan organisms are dependent on a continuous supply of O 2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca 2+ signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogram- ming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively.
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U2 - 10.1152/physiol.00045.2009
DO - 10.1152/physiol.00045.2009
M3 - Article
C2 - 19364912
SN - 1548-9213
VL - 24
SP - 97
EP - 106
JO - Physiology
JF - Physiology
IS - 2
ER -