Regulation of oxygen homeostasis by hypoxia-Inducible factor 1

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Metazoan organisms are dependent on a continuous supply of O 2 for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca 2+ signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogram- ming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
Issue number2
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Physiology


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