Regulation of nicotinic acetylcholine receptors by protein phosphorylation

Kathryn Miles, Richard L. Huganir

Research output: Contribution to journalArticlepeer-review

Abstract

Neurotransmitter receptors and ion channels play a critical role in the transduction of signals at chemical synapses. The modulation of neurotransmitter receptor and ion channel function by protein phosphorylation is one of the major regulatory mechanisms in the control of synaptic transmission. The nicotinic acetylcholine receptor (nAcChR) has provided an excellent model system in which to study the modulation of neurotransmitter receptors and ion channels by protein phosphorylation since the structure and function of this receptor have been so extensively characterized. In this article, the structure of the nAcChR from the electric organ of electric fish, skeletal muscle, and the central and peripheral nervous system will be briefly reviewed. Emphasis will be placed on the regulation of the phosphorylation of nAcChR by second messengers and by neurotransmitters and hormones. In addition, recent studies on the functional modulation of nicotinic receptors by protein phosphorylation will be reviewed.

Original languageEnglish (US)
Pages (from-to)91-124
Number of pages34
JournalMolecular Neurobiology
Volume2
Issue number2
DOIs
StatePublished - Jun 1988

Keywords

  • cAMP-dependent protein kinase
  • desensitization, ion channels
  • neuropeptides
  • neurotransmitter receptor
  • protein kinase
  • protein kinase C
  • receptor-receptor interactions
  • second messengers
  • tyrosine kinase

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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