Regulation of natural killer activity in vivo. II. The effect of alcohol consumption on human peripheral blood natural killer activity

Queen B. Saxena, Esteban Mezey, William H. Adler

Research output: Contribution to journalArticle

Abstract

Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4‐h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in the control group. NK activity of PBL from alcoholics was still higher than that of similarly treated PBL from control subjects after carbonyl iron and magnet treatment, or after passage through a nylon wool column or after removal of cells rosetting with sheep erythrocytes. Changes in T cell, B cell or macrophage populations, therefore, are not the mechanism for increased NK activity in alcoholics.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalInternational Journal of Cancer
Volume26
Issue number4
DOIs
StatePublished - Oct 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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