Regulation of mitochondrial respiratory chain structure and function by estrogens/estrogen receptors and potential physiological/pathophysiological implications

Jin Qiang Chen, James D. Yager, Jose Russo

Research output: Contribution to journalReview articlepeer-review

Abstract

It is well known that the biological and carcinogenic effects of 17β-estradiol (E2) are mediated via nuclear estrogen receptors (ERs) by regulating nuclear gene expression. Several rapid, non-nuclear genomic effects of E2 are mediated via plasma membrane-bound ERs. In addition, there is accumulating evidence suggesting that mitochondria are also important targets for the action of estrogens and ERs. This review summarized the studies on the effects of estrogens via ERs on mitochondrial structure and function. The potential physiological and pathophysiological implications of deficiency and/or overabundance of these E2/ER-mediated mitochondrial effects in stimulation of cell proliferation, inhibition of apoptosis, E 2-mediated cardiovascular and neuroprotective effects in target cells are also discussed.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1746
Issue number1
DOIs
StatePublished - Oct 30 2005

Keywords

  • 17β-estradiol
  • Estrogen
  • Estrogen carcinogenesis
  • Estrogen receptors α and β
  • Mitochondria
  • Mitochondrial DNA transcription
  • Mitochondrial DNA-encoded gene
  • Mitochondrial estrogen receptor
  • Mitochondrial respiratory chain (MRC)

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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