Mitochondria are responsible for ATP production but are also known as regulators of cell death, and mitochondrial matrix Cabsup2+esup is a key modulator of both ATP production and cell death. Although mitochondrial Cabsup2+esup uptake and efflux have been studied for over 50 years, it is only in the past decade that the proteins responsible for mitochondrial Cabsup2+esup uptake and efflux have been identified. The identification of the mitochondrial Cabsup2+esup uniporter (MCU) led to an explosion of studies identifying regulators of the MCU. The levels of these regulators vary in a tissue- and disease-specific manner, providing new insight into how mitochondrial Cabsup2+esup is regulated. This review focuses on the proteins responsible for mitochondrial transport and what we have learned from mouse studies with genetic alterations in these proteins.
|Original language||English (US)|
|Number of pages||20|
|Journal||Annual review of physiology|
|State||Published - Feb 10 2021|
ASJC Scopus subject areas