Regulation of metanephric kidney development by growth/differentiation factor 11

Aurora F. Esquela, Se Jin Lee

Research output: Contribution to journalArticle

Abstract

Growth/differentiation factor 11 (Gdf11) is a transforming growth factor β family member previously shown to control anterior/posterior patterning of the axial skeleton. We now report that Gdf11 also regulates kidney organogenesis. Mice carrying a targeted deletion of Gdf11 possess a spectrum of renal abnormalities with the majority of mutant animals lacking both kidneys. Histological analysis revealed a failure in ureteric bud formation at the initial stage of metanephric development in most Gdf11 mutant embryos examined. The metanephric mesenchyme of mutant embryos lacking a ureteric bud was found to be defective in the expression of glial cell line-derived neurotrophic factor (Gdnf), a gene known to direct ureteric bud outgrowth. The addition of Gdnf protein to urogenital tracts taken from Gdf11 null embryos induced ectopic ureteric bud formation along the Wolffian duct. Our studies suggest that Gdf11 may be important in directing the initial outgrowth of the ureteric bud from the Wolffian duct by controlling the expression of Gdnf in the metanephric mesenchyme.

Original languageEnglish (US)
Pages (from-to)356-370
Number of pages15
JournalDevelopmental biology
Volume257
Issue number2
DOIs
StatePublished - May 15 2003

Keywords

  • Gdf11
  • Gdnf
  • Kidney organogenesis
  • Metanephric development
  • Ureteric bud

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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