TY - JOUR
T1 - Regulation of lipid metabolism
T2 - A tale of two yeasts
AU - Raychaudhuri, Sumana
AU - Young, Barry P.
AU - Espenshade, Peter J.
AU - Loewen, Christopher J.R.
N1 - Funding Information:
We extend a sincere apology to those whose work was not discussed or cited in this review owing to limitations in space and scope. This work was supported by grants from the National Institutes of Health HL077588 (PJE); and NSERC , CIHR , MSFHR , and CFI (CJRL). PJE is an Established Investigator of the American Heart Association. CJRL is a recipient of a CIHR New Investigator and a MSFHR Junior Scholar award.
PY - 2012/8
Y1 - 2012/8
N2 - Eukaryotic cells synthesize multiple classes of lipids by distinct metabolic pathways in order to generate membranes with optimal physical and chemical properties. As a result, complex regulatory networks are required in all organisms to maintain lipid and membrane homeostasis as well as to rapidly and efficiently respond to cellular stress. The unicellular nature of yeast makes it particularly vulnerable to environmental stress and yeast has evolved elaborate signaling pathways to maintain lipid homeostasis. In this article we highlight the recent advances that have been made using the budding and fission yeasts and we discuss potential roles for the unfolded protein response (UPR) and the SREBP-Scap pathways in coordinate regulation of multiple lipid classes.
AB - Eukaryotic cells synthesize multiple classes of lipids by distinct metabolic pathways in order to generate membranes with optimal physical and chemical properties. As a result, complex regulatory networks are required in all organisms to maintain lipid and membrane homeostasis as well as to rapidly and efficiently respond to cellular stress. The unicellular nature of yeast makes it particularly vulnerable to environmental stress and yeast has evolved elaborate signaling pathways to maintain lipid homeostasis. In this article we highlight the recent advances that have been made using the budding and fission yeasts and we discuss potential roles for the unfolded protein response (UPR) and the SREBP-Scap pathways in coordinate regulation of multiple lipid classes.
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U2 - 10.1016/j.ceb.2012.05.006
DO - 10.1016/j.ceb.2012.05.006
M3 - Review article
C2 - 22694927
AN - SCOPUS:84865303699
SN - 0955-0674
VL - 24
SP - 502
EP - 508
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -