Regulation of ion channels and arrhythmias in the ischemic heart

Joseph G. Akar, Fadi G. Akar

Research output: Contribution to journalArticle

Abstract

Ventricular arrhythmias in the setting of ischemic heart disease is a leading cause of mortality in the United States. A better understanding of the complex changes associated with ischemic injury is likely to improve our ability to design better treatment strategies for patients who have coronary events. A major difficulty in treating those patients arises from the complexity of the electrophysiological changes that occur with varying time courses during the ischemic episode and the reperfusion phase. Here, we discuss some of the key cellular and network electrophysiological changes that are associated with ischemic injury and highlight the link between alterations in the energetic/metabolic substrate of the heart and electrical dysfunction.

Original languageEnglish (US)
JournalJournal of Electrocardiology
Volume40
Issue number6 SUPPL. 1
DOIs
StatePublished - Nov 2007

Fingerprint

Ion Channels
Cardiac Arrhythmias
Wounds and Injuries
Reperfusion
Myocardial Ischemia
Mortality
Therapeutics

Keywords

  • Arrhythmias
  • Ischemia
  • Metabolism
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Regulation of ion channels and arrhythmias in the ischemic heart. / Akar, Joseph G.; Akar, Fadi G.

In: Journal of Electrocardiology, Vol. 40, No. 6 SUPPL. 1, 11.2007.

Research output: Contribution to journalArticle

Akar, Joseph G. ; Akar, Fadi G. / Regulation of ion channels and arrhythmias in the ischemic heart. In: Journal of Electrocardiology. 2007 ; Vol. 40, No. 6 SUPPL. 1.
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