Regulation of intestinal electroneutral sodium absorption and the brush border Na+H+ exchanger by intracellular calcium

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The intestinal electroneutral Na+ absorptive processes account for most small intestinal Na+ absorption in the period between meals and also for the great majority of the increase in ileal Na+ absorption that occurs postprandially. In most diarrheal diseases, there is inhibition of neutral NaCl absorption. Elevated levels of intracellular calcium ([Ca2+]i) are known to inhibit NaCl absorption and involve multiple components of the Ca2+ signaling pathway. The BB Na +H+ exchanger NHE3 accounts for most of the recognized digestive changes in neutral NaCl absorption, as well as most of the changes in Na+ absorption that occur in diarrheal diseases. Previous studies have examined several aspects of Ca2+ regulation of NHE3 activity. These include phosphorylation, protein trafficking, and multiprotein complex formation. In addition, recent studies have demonstrated the role of the NHERF family of PDZ domain-containing proteins in Ca2+ regulation of NHE3 activity, thereby adding a new level of complexity to understanding Ca 2+-dependent inhibition of Na+ absorption. In this article, we will review the current understanding of (1) Ca2+ signaling events in intestinal epithelial cells; (2) Ca2+ regulation of intestinal electroneutral sodium absorption, which includes NHE3; and (3) the role of the NHERF family of PDZ domain-containing proteins in Ca2+ regulation of NHE3 activity. We will also present new data on using advanced imaging showing rapid BB NHE3 endocytosis in response to elevated [Ca 2+]i.

Original languageEnglish (US)
Title of host publicationMolecular Structure and Function of the Tight Junction From Basic Mechanisms to Clinical Manifestations
PublisherBlackwell Publishing Inc.
Pages240-248
Number of pages9
ISBN (Print)9781573317498
DOIs
StatePublished - May 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1165
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Intracellular calcium
  • NHE3
  • NHERF

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Zachos, N. C., Kovbasnjuk, O., & Donowitz, M. (2009). Regulation of intestinal electroneutral sodium absorption and the brush border Na+H+ exchanger by intracellular calcium. In Molecular Structure and Function of the Tight Junction From Basic Mechanisms to Clinical Manifestations (pp. 240-248). (Annals of the New York Academy of Sciences; Vol. 1165). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04055.x