Regulation of inflammatory and antiviral signaling by A20

Kislay Parvatiyar, Edward W. Harhaj

Research output: Contribution to journalShort surveypeer-review

Abstract

The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalMicrobes and Infection
Volume13
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • A20
  • Antiviral signaling
  • IKK
  • Inflammation
  • NF-κB
  • Ubiquitin

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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