Regulation of inflammatory and antiviral signaling by A20

Kislay Parvatiyar; Edward W. Harhaj

doi:10.1016/j.micinf.2010.11.003

Regulation of inflammatory and antiviral signaling by A20

Kislay Parvatiyar, Edward W. Harhaj

Research output: Contribution to journal › Short survey › peer-review

26 Scopus citations

Abstract

The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.

Original language	English (US)
Pages (from-to)	209-215
Number of pages	7
Journal	Microbes and Infection
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.micinf.2010.11.003
State	Published - Mar 2011
Externally published	Yes

Keywords

A20
Antiviral signaling
IKK
Inflammation
NF-κB
Ubiquitin

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2010.11.003

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title = "Regulation of inflammatory and antiviral signaling by A20",

abstract = "The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.",

keywords = "A20, Antiviral signaling, IKK, Inflammation, NF-κB, Ubiquitin",

author = "Kislay Parvatiyar and Harhaj, {Edward W.}",

note = "Funding Information: The laboratory of E.W.H. is supported by NIH grants PO1CA128115 , RO1CA135362 and RO1GM083143 .",

year = "2011",

month = mar,

doi = "10.1016/j.micinf.2010.11.003",

language = "English (US)",

volume = "13",

pages = "209--215",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson SAS",

number = "3",

}

TY - JOUR

T1 - Regulation of inflammatory and antiviral signaling by A20

AU - Parvatiyar, Kislay

AU - Harhaj, Edward W.

N1 - Funding Information: The laboratory of E.W.H. is supported by NIH grants PO1CA128115 , RO1CA135362 and RO1GM083143 .

PY - 2011/3

Y1 - 2011/3

N2 - The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.

AB - The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.

KW - A20

KW - Antiviral signaling

KW - IKK

KW - Inflammation

KW - NF-κB

KW - Ubiquitin

UR - http://www.scopus.com/inward/record.url?scp=78951476966&partnerID=8YFLogxK

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U2 - 10.1016/j.micinf.2010.11.003

DO - 10.1016/j.micinf.2010.11.003

M3 - Short survey

C2 - 21111841

AN - SCOPUS:78951476966

SN - 1286-4579

VL - 13

SP - 209

EP - 215

JO - Microbes and Infection

JF - Microbes and Infection

IS - 3

ER -

Regulation of inflammatory and antiviral signaling by A20

Abstract

Keywords

ASJC Scopus subject areas

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