Abstract
T lymphocytes from rats infected with Nippostrongylus brasiliensis (Nb) release a soluble factor with affinity for IgE that selectively potentiates the IgE response to an unrelated antigen. The factor is derived from Fc(ε) receptors on T cells, binds to surface IgE on precursors of IgE-forming cells, and enhances their differentiation. The factor has a molecular weight of between 10,000 to 20,000 and an affinity for lentil lectin. T cells from Nb-infected rats formed another IgE-binding factor upon incubation with rat IgE. The factor has the ability to suppress rather than enhance the IgE response. The IgE-specific suppressive factor is comparable to IgE-potentiating factor with respect to molecular weight and affinity for IgE but it fails to bind to lentil lectin. The IgE-specific suppressive factor is formed by lymphocytes from complete Freund's adjuvant-treated rats. The results strongly suggest that IgE-binding factors are involved in the regulation of IgE response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2162-2166 |
| Number of pages | 5 |
| Journal | Federation Proceedings |
| Volume | 40 |
| Issue number | 8 |
| State | Published - 1981 |
ASJC Scopus subject areas
- General Medicine